國家衛生研究院 NHRI:Item 3990099045/6495
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    题名: 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
    作者: Hsu, JT;Yeh, TK;Yen, SC;Chen, CT;Hsieh, SY;Hsu, T;Lu, CT;Chen, CH;Chou, LH;Chiu, CH;Chang, YI;Tseng, YJ;Yen, KR;Chao, YS;Lin, WH;Jiaang, WT
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A new class of FLT3 inhibitors has been identified based on the 3-phenyl-1H-5-pyrazolylamine scaffold. The structure-activity relationships led to the discovery of two carbamate series, and some potent compounds within these two series exhibited better growth inhibition of FLT3-mutated MOLM-13 cells than FLT3 inhibitors sorafenib (2) and ABT-869 (3). In particular, compound 8d exhibited the ability to regress tumors in mouse xenograft model using MOLM-13 cells.
    日期: 2012-06-07
    關聯: Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2012.05.116
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306101300031
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863441042
    显示于类别:[蔣維棠] 期刊論文
    [陳炯東] 期刊論文
    [葉燈光] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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