國家衛生研究院 NHRI:Item 3990099045/6999

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Periodical Articles > Item 3990099045/6999

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6999

Title:	Cytotoxic cardenolide glycosides from the root of Reevesia formosana
Authors:	Chang, HS;Chiang, MY;Hsu, HY;Yang, CW;Lin, CH;Lee, SJ;Chen, IS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Bioassay-guided fractionation of the root tissue of Reevesia formosana led to isolation of 13 cardenolide glycosides, reevesiosides A–I and epi-reevesiosides F–I. Their structures were determined by means of spectroscopic analysis and single-crystal X-ray diffraction was performed using reevesioside A. Reevesioside A, reevesioside F, and epi-reevesioside F displayed especially potent cytotoxicity against the MCF-7 and NCI-H460 cancer cell lines, with IC50 values of 63 ± 2 and 19 ± 1, 72 ± 8 and 20 ± 0, and 34 ± 6 and 10 ± 1 nM, respectively. Identification of the sugar constituents and unusual 18,20-epoxide cardenolide glycosides are described herein. Cardiac glycosides were previously unknown in the Sterculiaceae family.
Date:	2013-03
Relation:	Phytochemistry. 2013 Mar;87:86-95.
Link to:	http://dx.doi.org/10.1016/j.phytochem.2012.11.024
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9422&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000315078900010
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872769690
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles

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