國家衛生研究院 NHRI:Item 3990099045/6999
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2478896      線上人數 : 93
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6999


    題名: Cytotoxic cardenolide glycosides from the root of Reevesia formosana
    作者: Chang, HS;Chiang, MY;Hsu, HY;Yang, CW;Lin, CH;Lee, SJ;Chen, IS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Bioassay-guided fractionation of the root tissue of Reevesia formosana led to isolation of 13 cardenolide glycosides, reevesiosides A–I and epi-reevesiosides F–I. Their structures were determined by means of spectroscopic analysis and single-crystal X-ray diffraction was performed using reevesioside A. Reevesioside A, reevesioside F, and epi-reevesioside F displayed especially potent cytotoxicity against the MCF-7 and NCI-H460 cancer cell lines, with IC50 values of 63 ± 2 and 19 ± 1, 72 ± 8 and 20 ± 0, and 34 ± 6 and 10 ± 1 nM, respectively. Identification of the sugar constituents and unusual 18,20-epoxide cardenolide glycosides are described herein. Cardiac glycosides were previously unknown in the Sterculiaceae family.
    日期: 2013-03
    關聯: Phytochemistry. 2013 Mar;87:86-95.
    Link to: http://dx.doi.org/10.1016/j.phytochem.2012.11.024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9422&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000315078900010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872769690
    顯示於類別:[李秀珠] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO0031942212005195.pdf564KbAdobe PDF614檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋