國家衛生研究院 NHRI:Item 3990099045/6999
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    题名: Cytotoxic cardenolide glycosides from the root of Reevesia formosana
    作者: Chang, HS;Chiang, MY;Hsu, HY;Yang, CW;Lin, CH;Lee, SJ;Chen, IS
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Bioassay-guided fractionation of the root tissue of Reevesia formosana led to isolation of 13 cardenolide glycosides, reevesiosides A–I and epi-reevesiosides F–I. Their structures were determined by means of spectroscopic analysis and single-crystal X-ray diffraction was performed using reevesioside A. Reevesioside A, reevesioside F, and epi-reevesioside F displayed especially potent cytotoxicity against the MCF-7 and NCI-H460 cancer cell lines, with IC50 values of 63 ± 2 and 19 ± 1, 72 ± 8 and 20 ± 0, and 34 ± 6 and 10 ± 1 nM, respectively. Identification of the sugar constituents and unusual 18,20-epoxide cardenolide glycosides are described herein. Cardiac glycosides were previously unknown in the Sterculiaceae family.
    日期: 2013-03
    關聯: Phytochemistry. 2013 Mar;87:86-95.
    Link to: http://dx.doi.org/10.1016/j.phytochem.2012.11.024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9422&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000315078900010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872769690
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