邻近类别 會議論文/會議摘要 [30/48] 專利 [0/42] 类别统计 近3年内发表的文件:13(9.15%) 含全文笔数:142(100.00%) 文件下载次数统计 下载大于0次:142(100.00%) 下载大于100次:138(97.18%) 全文下载总次数:84253(82.39%) 最后更新时间: 2024-12-12 08:20 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 Discovery of novel TANK-Binding Kin... DBPR116, a prodrug of BPRMU191, in ... Discovery of dual MER/AXL kinase in... Macrophage-mediated controlled rele... Targeting cathepsin S promotes acti... Influence of ring strain on the for... A dual nociceptin and mu opioid rec... Development of furanopyrimidine-bas... A critical overview of current prog... Recent advances in total synthesis ...

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显示项目1-50 / 142. (共3页) 1 2 3 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2024-12	Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma	International Journal of Biological Macromolecules. 2024 Dec;283(Part 1):Article number 137296.
2024-11	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790.
2024-06-24	Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease	European Polymer Journal. 2024 Jun 24;214:Article number 113151.
2024-06-24	Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment	Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
2024-05-09	Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function	Journal of Biomedical Science. 2024 May 09;31:Article number 46.
2023-11-03	Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone	Organic Letters. 2023 Nov 3;25(43):7757-7762.
2023-10-05	A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects	European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
2023-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2022-09-12	A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies	Journal of Biomedical Science. 2022 Sep 12;29:Article number 68.
2022-08-09	Recent advances in total synthesis of natural products by masked ortho-benzoquinones	Journal of the Chinese Chemical Society. 2022 Aug 09;69(8):1210-1222.
2022-05-09	Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer	Journal of Biomedical Science. 2022 May 9;29:Article number 29.
2022-04-06	Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2	International Journal of Molecular Sciences. 2022 Apr 6;23(7):Article number 4050.
2022-01-21	Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma	Journal of Biomedical Science. 2022 Jan 21;29:Article number 5.
2021-11-15	Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization	European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673.
2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
2021-07-16	Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens	Nanomaterials. 2021 Jul 16;11(7):Article number 1844.
2021-04-16	Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors	Organic Process Research and Development. 2021 Apr 16;25(4):817-830.
2021-04-13	Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)	Tetrahedron Letters. 2021 Apr 13;69:Article number 152976.
2021-02-22	Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design	ACS Omega. 2021 Feb 22;6(9):6100-6111.
2021-01-31	Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908)	Marine Drugs. 2021 Jan 31;19(2):Article number 77.
2021-01-15	One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C	Journal of Organic Chemistry. 2021 Jan 15;86(2):1955-1963.
2021-01	Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors	Chemical Biology and Drug Design. 2021 Jan;97(1):51-66.
2020-12-10	Tumor-agnostic inhibitors in oncology: A new phase for precision medicine	Journal of the Chinese Chemical Society. 2020 Dec 10;67(12):2216-2224.
2020-08	Design of a potent anticancer lead inspired by natural products from traditional Indian medicine	Journal of Biomolecular Structure and Dynamics. 2020 Aug;38(12):3563-3577.
2020-07	Design of drug-like hepsin inhibitors against prostate cancer and kidney stones	Acta Pharmaceutica Sinica B. 2020 Jul;10(7):1309-1320.
2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	Bioorganic Chemistry. 2020 May;98:Article number 103689.
2020-03-01	A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis	Cancer Letters. 2020 Mar 1;472:97-107.
2020-01	Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening	Biochimie. 2020 Jan;168:220-230.
2019-12	Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry	Biochimica et Biophysica Acta. Molecular Cell Research. 2019 Dec;1866(12):Article number 118517.
2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-10-08	Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity	Advanced Therapeutics. 2019 Oct 8;2(12):Article number 1900105.
2019-07-03	Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study	Journal of Biomolecular Structure and Dynamics. 2019 Jul 3;37(10):2581-2592.
2019-07	Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation	Scientific Reports. 2019 Jul;9:Article number 9943.
2019-05-29	Insights for the design of protein lysine methyltransferase G9a inhibitors	Future Medicinal Chemistry. 2019 May 29;11(9):993-1014.
2018-11	Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D	Angewandte Chemie. 2018 Nov;57(47):15572-15576.
2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	European Journal of Medicinal Chemistry. 2018 May 10;151:533-545.
2018-04-25	Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors	European Journal of Medicinal Chemistry. 2018 Apr 25;150:491-505.
2017-08-11	Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer	Scientific Reports. 2017 Aug 11;7:Article number 7972.
2017-07	Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors	Journal of Biomolecular Structure and Dynamics. 2017 Jun;35(8):1833-1848.
2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Oncotarget. 2016 Dec;7(52):86239-86256.
2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	European Journal of Medicinal Chemistry. 2016 Nov 29;124:186-199.
2016-07	Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792	Expert Opinion on Therapeutic Patents. 2016 Jul;26(7):751-755.
2016-03	Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin	RSC Advances. 2016 Mar;6(38):31947-31959.
2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	Scientific Reports. 2015 Jun 29;5:Article number 11702.
2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	Journal of Medicinal Chemistry. 2015 Feb;58(3):1452-1465.
2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	Journal of Computer-Aided Molecular Design. 2015 Jan;29(1):89-100.
2014-12	BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71	Antiviral Research. 2014 Dec;112:18-25.
2014-10	Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer	Expert Opinion on Investigational Drugs. 2014 Oct;23(10):1333-1348.
2014-08	CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors	International Journal of Cancer. 2014 Aug;135(3):751-762.
2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	European Journal of Medicinal Chemistry. 2014 Aug;83:226-235.

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