國家衛生研究院 NHRI:作者相关文件

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"Song, JS"的相关文件

类别	日期	题名	關聯
[伍素瑩] 期刊論文	2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	-
[伍素瑩] 期刊論文	2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	-
[伍素瑩] 期刊論文	2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	-
[伍素瑩] 期刊論文	2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	-
[伍素瑩] 期刊論文	2009-07-23	Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity	-
[其他] 期刊論文	2022-08-09	Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes	-
[其他] 期刊論文	2017-09	trans-stilbene C-glycosides: Synthesis by a microwave-assisted heck reaction and evaluation of the SGLT-2 inhibitory activity	-
[其他] 期刊論文	2013-11	Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors	-
[夏克山] 專利	2011-10-01	硒吩化合物及其醫藥組成物	-
[夏克山] 專利	2011-08-11	噁二唑化合物	-
[夏克山] 專利	2010-09-28	Selenophene compounds	-
[夏克山] 專利	2010-04-27	Oxadiazole compounds	-
[夏克山] 期刊論文	2022-10-03	Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention	-
[夏克山] 期刊論文	2021-03-30	A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment	-
[夏克山] 期刊論文	2021-03-02	Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties	-
[夏克山] 期刊論文	2019-01-01	Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist	-
[夏克山] 期刊論文	2018-07	Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology	-
[夏克山] 期刊論文	2018-02-08	Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond	-
[夏克山] 期刊論文	2016-01	Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions	-
[夏克山] 期刊論文	2015-06-15	Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents	-
[夏克山] 期刊論文	2015-03	Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury	-
[夏克山] 期刊論文	2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	-
[夏克山] 期刊論文	2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	-
[夏克山] 期刊論文	2012-02	Discovery of novel stem cell mobilizers that target the CXCR4 receptor	-
[夏克山] 期刊論文	2010-09	Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist	-
[夏克山] 期刊論文	2009-07-23	Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice	-
[夏克山] 期刊論文	2008-09-21	Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists	-
[夏克山] 期刊論文	2008-09-11	Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists	-
[夏克山] 期刊論文	2008-02-07	Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists	-
[岳嶽] 期刊論文	2019-12	A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses	-
[岳嶽] 期刊論文	2013-05	Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus	-
[張俊彥] 期刊論文	2022-03-02	Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy	-
[徐祖安] 期刊論文	2012-01	A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors	-
[李秀珠] 期刊論文	2017-07	Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors	-
[李靜琪] 期刊論文	2024-04	Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles	-
[李靜琪] 期刊論文	2023-10-05	Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease	-
[李靜琪] 期刊論文	2020-02	Design, synthesis and anticancer evaluation of beta-carboline-1-one hydantoins	-
[李靜琪] 期刊論文	2019-03	Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors	-
[李靜琪] 期刊論文	2018-01-01	Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2	-
[李靜琪] 期刊論文	2016-05	N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors	-
[李靜琪] 期刊論文	2015-07	Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors	-
[李靜琪] 期刊論文	2012-09	Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors	-
[洪明秀] 會議論文/會議摘要	2016-12	Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy	-
[洪明秀] 期刊論文	2023-01	Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists	-
[王昀] 期刊論文	2020-09-25	Protective effect of CXCR4 antagonist CX807 in a rat model of hemorrhagic stroke	-
[石全(2014-2017)] 會議論文/會議摘要	2020-08	BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification	-
[紀雅惠] 會議論文/會議摘要	2019-07	An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer	-
[紀雅惠] 期刊論文	2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	-
[紀雅惠] 期刊論文	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	-
[翁紹華] 會議論文/會議摘要	2018-07	4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo	-
[翁紹華] 期刊論文	2023-11-15	Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors	-
[翁紹華] 期刊論文	2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	-
[翁紹華] 期刊論文	2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	-
[翁紹華] 期刊論文	2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	-
[翁紹華] 期刊論文	2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	-
[葉燈光] 期刊論文	2013-11	BPR0C305, an orally active microtubule-disrupting anticancer agent	-
[蔣維棠] 期刊論文	2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	-
[蔣維棠] 期刊論文	2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	-
[蔣維棠] 期刊論文	2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	-
[謝興邦] 會議論文/會議摘要	2009-09	Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development	-
[謝興邦] 會議論文/會議摘要	2002-08	Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents	-
[謝興邦] 期刊論文	2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[謝興邦] 期刊論文	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	-
[謝興邦] 期刊論文	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	-
[謝興邦] 期刊論文	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	-
[謝興邦] 期刊論文	2002-06-06	Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents	-
[趙宇生(2002-2013)] 期刊論文	2015-07	Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells	-
[趙宇生(2002-2013)] 期刊論文	2012-02	Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents	-
[趙宇生(2002-2013)] 期刊論文	2011-01-13	Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes	-
[趙宇生(2002-2013)] 期刊論文	2010-08	Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein	-
[趙宇生(2002-2013)] 期刊論文	2010-07	Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075	-
[鄒倫] 期刊論文	2019-05	Characterization, dynamics, and mechanism of CXCR4 antagonists on a constitutively active mutant	-
[陳志豪] 期刊論文	2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	-
[陳怡榮] 期刊論文	2008-06-01	A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors	-
[陳新(2002-2015)] 期刊論文	2010-06-15	(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	-
[陳炯東] 期刊論文	2021-08-01	DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity	-
[陳炯東] 期刊論文	2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	-
[陳炯東] 期刊論文	2020-08	Artificial intelligence approach fighting COVID-19 with repurposing drugs	-
[陳炯東] 期刊論文	2019-09	Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1	-
[陳炯東] 期刊論文	2011-01	BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities	-
[陳炯東] 期刊論文	2010-12	Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening	-
[陳炯東] 期刊論文	2010-03	Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents	-
[陳炯東] 期刊論文	2003-04-24	Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents	-
[陳立宗] 期刊論文	2003-06-15	Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent	-

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