國家衛生研究院 NHRI:Item 3990099045/1249

NHRI > Institute of Biotechnology and Pharmaceutical Research > Weir-Torn Jiaang > Periodical Articles > Item 3990099045/1249

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1249

Title:	Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Authors:	Tsai, TY;Coumar, MS;Hsu, T;Hsieh, HP;Chien, CH;Chen, CT;Chang, CN;Lo, YK;Wu, SH;Huang, CY;Huang, YW;Wang, MH;Wu, HY;Lee, HJ;Chen, X;Chao, YS;Jiaang, WT
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:	Chemistry, Medicinal;Chemistry, Organic
Date:	2006-06-15
Relation:	Bioorganic and Medicinal Chemistry Letters. 2006 Jun;16(12):3268-3272.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2006.03.037
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000237763500039
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646494486
Appears in Collections:	[Weir-Torn Jiaang] Periodical Articles [Hsing-Pang Hsieh] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Xin Chen(2002-2015)] Periodical Articles [Chiung-Tong Chen] Periodical Articles

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