國家衛生研究院 NHRI:Item 3990099045/3552

NHRI > Institute of Biotechnology and Pharmaceutical Research > Weir-Torn Jiaang > Periodical Articles > Item 3990099045/3552

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3552

Title:	Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors
Authors:	Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Chiou, MC;Huang, CH;Tseng, YJ;Yeh, TK;Huang, CY;Yeh, KC;Huang, YW;Wu, SH;Wang, MH;Chen, X;Chao, YS;Jiaang, WT
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of (2S)-cyanopyrrolidines with glutamic acid derivatives at the P2 site have been prepared and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV). The structure-activity relationships (SAR) led to the discovery of potent 3-substituted glutamic acid analogues, providing enhanced chemical stability and excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. Compound 13f exhibited the ability to both significantly decrease the glucose excursion and inhibit plasma DPP-IV activity. ? 2009 Elsevier Ltd. All rights reserved.
Date:	2009-04-01
Relation:	Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2009.02.061
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000264169700015
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=62149152364
Appears in Collections:	[Weir-Torn Jiaang] Periodical Articles [Teng-Kuang Yeh] Periodical Articles [Xin Chen(2002-2015)] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Chiung-Tong Chen] Periodical Articles

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