國家衛生研究院 NHRI:Item 3990099045/3552
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    題名: Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors
    作者: Tsai, TY;Hsu, T;Chen, CT;Cheng, JH;Chiou, MC;Huang, CH;Tseng, YJ;Yeh, TK;Huang, CY;Yeh, KC;Huang, YW;Wu, SH;Wang, MH;Chen, X;Chao, YS;Jiaang, WT
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: A series of (2S)-cyanopyrrolidines with glutamic acid derivatives at the P2 site have been prepared and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV). The structure-activity relationships (SAR) led to the discovery of potent 3-substituted glutamic acid analogues, providing enhanced chemical stability and excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. Compound 13f exhibited the ability to both significantly decrease the glucose excursion and inhibit plasma DPP-IV activity. ? 2009 Elsevier Ltd. All rights reserved.
    日期: 2009-04-01
    關聯: Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2009.02.061
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000264169700015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=62149152364
    顯示於類別:[蔣維棠] 期刊論文
    [葉燈光] 期刊論文
    [陳新(2002-2015)] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳炯東] 期刊論文

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