國家衛生研究院 NHRI:
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    近3年内发表的文件:13(9.15%)
    含全文笔数:142(100.00%)

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    下载大于0次:142(100.00%)
    下载大于100次:138(97.18%)
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    最后更新时间: 2024-12-04 15:56


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    显示项目1-25 / 142. (共6页)
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    日期题名關聯
    2024-12 Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma International Journal of Biological Macromolecules. 2024 Dec;283(Part 1):Article number 137296.
    2024-11 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790.
    2024-06-24 Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease European Polymer Journal. 2024 Jun 24;214:Article number 113151.
    2024-06-24 Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
    2024-05-09 Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function Journal of Biomedical Science. 2024 May 09;31:Article number 46.
    2023-11-03 Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone Organic Letters. 2023 Nov 3;25(43):7757-7762.
    2023-10-05 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
    2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
    2022-09-12 A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies Journal of Biomedical Science. 2022 Sep 12;29:Article number 68.
    2022-08-09 Recent advances in total synthesis of natural products by masked ortho-benzoquinones Journal of the Chinese Chemical Society. 2022 Aug 09;69(8):1210-1222.
    2022-05-09 Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer Journal of Biomedical Science. 2022 May 9;29:Article number 29.
    2022-04-06 Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2 International Journal of Molecular Sciences. 2022 Apr 6;23(7):Article number 4050.
    2022-01-21 Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma Journal of Biomedical Science. 2022 Jan 21;29:Article number 5.
    2021-11-15 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673.
    2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
    2021-07-16 Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens Nanomaterials. 2021 Jul 16;11(7):Article number 1844.
    2021-04-16 Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors Organic Process Research and Development. 2021 Apr 16;25(4):817-830.
    2021-04-13 Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908) Tetrahedron Letters. 2021 Apr 13;69:Article number 152976.
    2021-02-22 Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design ACS Omega. 2021 Feb 22;6(9):6100-6111.
    2021-01-31 Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908) Marine Drugs. 2021 Jan 31;19(2):Article number 77.
    2021-01-15 One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C Journal of Organic Chemistry. 2021 Jan 15;86(2):1955-1963.
    2021-01 Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors Chemical Biology and Drug Design. 2021 Jan;97(1):51-66.
    2020-12-10 Tumor-agnostic inhibitors in oncology: A new phase for precision medicine Journal of the Chinese Chemical Society. 2020 Dec 10;67(12):2216-2224.
    2020-08 Design of a potent anticancer lead inspired by natural products from traditional Indian medicine Journal of Biomolecular Structure and Dynamics. 2020 Aug;38(12):3563-3577.
    2020-07 Design of drug-like hepsin inhibitors against prostate cancer and kidney stones Acta Pharmaceutica Sinica B. 2020 Jul;10(7):1309-1320.

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