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    Items for Author "Lin, WH" 

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    Showing 85 items.

    Collection Date Title Relation Bitstream
    [彭汪嘉康(1996-2007)] 期刊論文 2001-08-15 Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system -
    [彭汪嘉康(1996-2007)] 期刊論文 2001-09-01 Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification -
    [林嬪嬪] 期刊論文 2006-01-05 Increased cytochrome P4501B1 gene expression in peripheral leukocytes of municipal waste incinerator workers -
    [謝興邦] 期刊論文 2006-07 Antiviral drug discovery against SARS-CoV -
    [林景太(1999-2007)] 期刊論文 2006-10-15 DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: Implications in tumor promotion -
    [張俊彥] 期刊論文 2008-02 A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells -
    [謝興邦] 期刊論文 2008-03-01 Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold -
    [陳怡榮] 期刊論文 2008-06-01 A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors -
    [謝興邦] 期刊論文 2009-02-26 Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity -
    [謝興邦] 會議論文/會議摘要 2009-03 Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors -
    [謝興邦] 期刊論文 2009-04-23 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists -
    [謝興邦] 會議論文/會議摘要 2009-09 Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development -
    [謝興邦] 期刊論文 2010-02-01 Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor -
    [謝興邦] 期刊論文 2010-06-15 Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification -
    [邱燕楓] 期刊論文 2010-08 SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes -
    [謝興邦] 會議論文/會議摘要 2010-08 Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models -
    [趙宇生(2002-2013)] 期刊論文 2010-10 Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists -
    [趙宇生(2002-2013)] 期刊論文 2010-10-28 Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency -
    [徐祖安] 期刊論文 2011-04-25 Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus -
    [張俊彥] 會議論文/會議摘要 2011-05 Pharmacokinetic study with novel anticanacer agents, MPTOB124 and MPTOB214 -
    [徐祖安] 期刊論文 2011-06-01 Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells -
    [蔣維棠] 期刊論文 2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [張俊彥] 期刊論文 2011-08 BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells -
    [謝興邦] 會議論文/會議摘要 2011-09-23 BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo -
    [徐祖安] 期刊論文 2012-01 BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML -
    [徐祖安] 期刊論文 2012-01 A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors -
    [謝興邦] 會議論文/會議摘要 2012-03-25 Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors -
    [張堯] 期刊論文 2012-06 Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9 -
    [蔣維棠] 期刊論文 2012-06-07 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [李俊賢] 期刊論文 2012-11 Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan -
    [趙宇生(2002-2013)] 會議論文/會議摘要 2012-11 BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia -
    [謝興邦] 期刊論文 2013-01 3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor -
    [張堯] 期刊論文 2013-02 Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and 9 that synergistically promote cell invasion in vitro -
    [謝興邦] 專利 2013-02-11 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 -
    [謝興邦] 會議論文/會議摘要 2013-04 Design and synthesis of Aurora kinase inhibitors as anticancer agents -
    [謝興邦] 會議論文/會議摘要 2013-04-07 3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor -
    [徐祖安] 期刊論文 2013-04-29 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment -
    [謝興邦] 期刊論文 2013-05 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules -
    [徐祖安] 期刊論文 2013-05 Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors -
    [蔣維棠] 期刊論文 2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) -
    [謝興邦] 期刊論文 2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor -
    [謝興邦] 專利 2013-08-13 Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors -
    [徐祖安] 期刊論文 2013-09-22 A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411] -
    [徐祖安] 期刊論文 2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer -
    [謝興邦] 會議論文/會議摘要 2014-03 Efficient virtual screening using ligand efficiency based approach -
    [楊重熙] 期刊論文 2014-04 Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies -
    [蔣維棠] 專利 2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 -
    [謝興邦] 期刊論文 2014-05 Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach -
    [徐祖安] 期刊論文 2014-05 Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014) -
    [謝興邦] 期刊論文 2014-08 Ligand efficiency based approach for efficient virtual screening of compound libraries -
    [謝興邦] 會議論文/會議摘要 2014-10 Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML -
    [謝興邦] 會議論文/會議摘要 2014-10 Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma -
    [何令君] 期刊論文 2015-01 Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone -
    [徐祖安] 期刊論文 2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity -
    [謝興邦] 期刊論文 2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification -
    [蔣維棠] 期刊論文 2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations -
    [謝興邦] 專利 2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 -
    [陳炯東] 會議論文/會議摘要 2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia -
    [伍素瑩] 期刊論文 2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) -
    [江宏哲] 期刊論文 2016-06-01 A RISK21 matrix for assessing the potential health risk of DDT from flower tea in Taiwan -
    [謝興邦] 期刊論文 2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design -
    [謝興邦] 期刊論文 2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [陳炯東] 會議論文/會議摘要 2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST -
    [葉燈光] 會議論文/會議摘要 2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation -
    [紀雅惠] 期刊論文 2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition -
    [廖本揚] 期刊論文 2019-03-13 Genome-wide microarray analysis suggests transcriptomic response may not play a major role in high- to low-altitude acclimation in harvest mouse (Micromys minutus) -
    [伍素瑩] 期刊論文 2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants -
    [紀雅惠] 會議論文/會議摘要 2019-07 An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer -
    [其他] 期刊論文 2019-08 The effect of antidementia drugs on mortality in patients with Alzheimer's disease -
    [葉燈光] 會議論文/會議摘要 2019-10 Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer -
    [謝興邦] 期刊論文 2019-11-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer -
    [紀雅惠] 期刊論文 2019-12 Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis -
    [蔣維棠] 期刊論文 2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia -
    [謝興邦] 期刊論文 2020-05 Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors -
    [陳炯東] 期刊論文 2020-08 Artificial intelligence approach fighting COVID-19 with repurposing drugs -
    [李秀珠] 期刊論文 2020-08 Repurposing old drugs as antiviral agents for coronaviruses -
    [石全(2014-2017)] 會議論文/會議摘要 2020-08 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification -
    [李岳倫] 期刊論文 2021-01-15 Unlocking the mystery of the therapeutic effects of Chinese medicine on cancer -
    [紀雅惠] 期刊論文 2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins -
    [其他] 期刊論文 2021-06 Network reorganization during verbal fluency test in fronto-temporal epilepsy: A functional near-infrared spectroscopy study -
    [謝興邦] 期刊論文 2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model -
    [謝興邦] 期刊論文 2021-11-15 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization -
    [陳立宗] 期刊論文 2022-04 Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials -
    [其他] 期刊論文 2022-05-20 Left frontotemporal region plays a key role in letter fluency task-evoked activation and functional connectivity in normal subjects: A functional near-infrared spectroscopy study -
    [謝興邦] 期刊論文 2024-06-24 Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment -

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