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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1249


    Title: Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
    Authors: Tsai, TY;Coumar, MS;Hsu, T;Hsieh, HP;Chien, CH;Chen, CT;Chang, CN;Lo, YK;Wu, SH;Huang, CY;Huang, YW;Wang, MH;Wu, HY;Lee, HJ;Chen, X;Chao, YS;Jiaang, WT
    Contributors: Division of Biotechnology and Pharmaceutical Research
    Abstract: A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats. (c) 2006 Elsevier Ltd. All rights reserved.
    Keywords: Chemistry, Medicinal;Chemistry, Organic
    Date: 2006-06-15
    Relation: Bioorganic and Medicinal Chemistry Letters. 2006 Jun;16(12):3268-3272.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2006.03.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000237763500039
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646494486
    Appears in Collections:[蔣維棠] 期刊論文
    [謝興邦] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳新(2002-2015)] 期刊論文
    [陳炯東] 期刊論文

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