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Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models |
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2024-11-26 |
Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: Sar, structural insights, and biological characterization |
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2024-02-15 |
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2023-04-19 |
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2023-03-21 |
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2022-10-21 |
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2022-09-27 |
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2022-09-21 |
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2022-07-25 |
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2022-07-15 |
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2022-06-28 |
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2022-05-23 |
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2022-04-12 |
Thiazole compounds as protein kinase inhibitors |
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2022-03-03 |
단백질 키나아제 억제제로서의 아미노티아졸 화합물 |
KR10-2372288/2022-03-03 |
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2022-03-02 |
Aminothiazole compounds and use thereof |
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2021-12-21 |
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2021-11-30 |
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2021-11-18 |
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2021-10-07 |
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2021-08-12 |
Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) |
Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301. |
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2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
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2021-05-11 |
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2021-01 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease |
European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938. |
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2020-12-23 |
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2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150. |
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2019-11-12 |
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2019-08-01 |
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2019-07 |
Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626. |
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2019-05-28 |
Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform |
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2019-05-28 |
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2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants |
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957. |
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2018-08-24 |
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor |
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2018-08-14 |
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2017-03-21 |
Pyrrolidine derivatives |
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2016-12 |
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2016-10 |
BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia |
Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333. |
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2016-08-30 |
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2016-06-23 |
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2016-04-12 |
Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) |
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2016-02-09 |
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2015-11-13 |
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2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations |
European Journal of Medicinal Chemistry. 2015 Jul;100:151-161. |
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2014-08-01 |
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2014-05-08 |
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2014-04-25 |
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2014-04-21 |
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2014-02-19 |
Pyrrolidine derivatives |
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2014-02 |
Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation |
PLoS ONE. 2014 Feb 13;9(2):Article number e88772. |
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