國家衛生研究院 NHRI:
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    日期題名關聯
    2025-01 Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models Pharmacological Research. 2025 Jan;211:Article number 107556.
    2024-11-26 Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: Sar, structural insights, and biological characterization Journal of Medicinal Chemistry. 2024 Nov 26;67(23):21106-21125.
    2024-02-15 Aminothiazole compounds as protein kinase inhibitors MY-201291-A/2024-02-15
    2023-04-19 Aminothiazole compounds as protein kinase inhibitors EP3638237/2023-04-19
    2023-03-21 Aminothiazole compounds as protein kinase inhibitors CA3064081/2023-03-21
    2022-07-25 Aminothiazole compounds as protein kinase inhibitors IN101988/2022-07-25
    2022-07-15 Compuestos de aminotiazol como inhibidores de la proteina quinasa MX393992/2022-07-15
    2022-05-23 Aminothiazole compounds as protein kinase inhibitors RU2772645/2022-05-23
    2022-03-03 단백질 키나아제 억제제로서의 아미노티아졸 화합물 KR10-2372288/2022-03-03
    2021-11-30 Aminothiazole compounds as protein kinase inhibitors NZ759327/2021-11-30
    2021-11-18 プロテインキナーゼ阻害剤としてのアミノチアゾール化合物 JP6979595/2021-11-18
    2021-10-07 Aminothiazole compounds as protein kinase inhibitors AU2018284249/2021-10-07
    2021-08-12 Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
    2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Life Sciences. 2021 Aug 1;278:Article number 119574.
    2021-01 Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938.
    2020-12-23 Aminothiazole compounds as protein kinase inhibitors ZA202000107/2020-12-23
    2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
    2019-08-01 作為蛋白激酶抑制劑的胺基噻唑化合物 TWI667236/2019-08-01
    2019-07 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626.
    2019-05-28 Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform Cancers. 2019 May 28;11(6):Article number 739.
    2019-05-28 Aminothiazole compounds as protein kinase inhibitors US10300061/2019-05-28
    2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
    2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor Cancer Science. 2018 Nov;109(11):3591-3601.
    2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST Annals of Oncology. 2016 Dec;27(Suppl. 9):Meeting Abstract 2P.
    2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.

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