國家衛生研究院 NHRI:
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    显示项目1-50 / 108. (共3页)
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    日期题名關聯
    2025-02 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin[Erratum:Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.] Biochemical Pharmacology. 2025 Feb;232:Article number 116753.
    2024-04-16 Inhibitors of positive strand RNA viruses US11957667/2024-04-16
    2024-02-15 Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice Biochemical and Biophysical Research Communications. 2024 Feb 15;704:Article number 149668.
    2023-08-11 正股核糖核酸病毒之抑制劑 TWI811724/2023-08-11
    2023-07-20 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
    2023-01-19 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] Pharmaceutics. 2023 Jan 19;15(2):Article number 342.
    2022-07-21 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.
    2022-02-17 Tyrphostin AG1024 suppresses coronaviral replication by downregulating JAK1 via an IR/IGF-1R independent proteolysis mediated by Ndfip1/2_NEDD4-like E3 ligase itch Pharmaceuticals. 2022 Feb 17;15(2):Article number 241.
    2021-08-13 Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 Frontiers in Pharmacology. 2021 Aug 13;12:Article number 706901.
    2020-12-14 Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives Frontiers in Pharmacology. 2020 Dec 14;11:Article number 606097.
    2020-12 Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis[Erratum:Biochemical Pharmacology. 2020 Oct;180:Article number 114122.] Biochemical Pharmacology. 2020 Dec;182:Article number 114287.
    2020-10 Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis Biochemical Pharmacology. 2020 Oct;180:Article number 114122.
    2020-08-20 Discovery of M protease inhibitors encoded by SARS-CoV-2 Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20.
    2020-08 Polyketide synthase gene expression in relation to chloromonilicin and melanin production in Monilinia fructicola Phytopathology. 2020 Aug;110(8):1465-1475.
    2020-08 Artificial intelligence approach fighting COVID-19 with repurposing drugs Biomedical Journal. 2020 Aug;43(4):355-362.
    2020-08 Repurposing old drugs as antiviral agents for coronaviruses Biomedical Journal. 2020 Aug;43(4):368-374.
    2020-02 The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation Biochemical Pharmacology. 2020 Feb;172:Article number 113741.
    2020-02 Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha Pharmacological Research. 2020 Feb;152:Article number 104581.
    2019-08-06 Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget[Erratum: Oncotarget. 2015 Feb;6(4):2148-2163.] Oncotarget. 2019 Aug 6;10(47):4919.
    2018-10 The cardenolide ouabain suppresses coronaviral replication via augmenting a Na(+)/K(+)-ATPase-dependent PI3K_PDK1 axis signaling Toxicology and Applied Pharmacology. 2018 Oct;56:90-97.
    2017-10 Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus Toxicology and Applied Pharmacology. 2017 Oct;332:129-137.
    2017-07 Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612.
    2017-06-22 Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity Scientific Reports. 2017 Jun 22;7:Article number 4105.
    2017-05-22 Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential RSC Advances. 2017 May 22;7(43):27040-27047.
    2016-10 Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana Phytochemistry. 2016 Oct;130:282-290.
    2016-04 Discovery and development of tylophorine derived dibenzoquinolines-33b compounds into therapeutic agents The FASEB Journal. 2016 Apr;30(1, Suppl.):Meeting Abstract lb56.
    2016-02-22 Guidelines for the use and interpretation of assays for monitoring autophagy [Erratum to: Autophagy. 2016 Jan 2;12(1):1-222.] Autophagy. 2016 Feb 22;12(2):443.
    2016-01-02 Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy. 2016 Jan 2;12(1):1-222.
    2015-07 Biological evaluation of secondary metabolites from the root of machilus obovatifolia Chemistry and Biodiversity. 2015 Jul;12(7):1057-1067.
    2015-04 Tylophorine compounds exert anti-cancer activity by targeting a ribonucleoprotein complex containing caprin-1 and c-Myc mRNA FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number LB132
    2015-02 Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget Oncotarget. 2015 Feb;6(4):2148-2163.
    2014-11 Chemical constituents and cytotoxic activities from the fruits of Reevesia formosana Planta Medica. 2014 Nov;80(16):1541.
    2014-11 Chemical constituents and cytotoxic activities from the root and the stem of Reevesia formosana Planta Medica. 2014 Nov;80(16):1541.
    2014-08 Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells Oncotarget. 2014 Aug;5(15):6087-6101.
    2014-05-11 二苯並〔f,h〕異喹啉衍生物及其醫藥組成物 TWI436983/2014-05-11
    2014-03-21 菲并吲哚啶類似物 TWI430794/2014-03-21
    2014-01 A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
    2013-07-16 Dibenzo[f,h]isoquinoline derivatives US8486959/2013-07-16
    2013-06 c-Jun-mediated anti-cancer mechanisms of tylophorine Carcinogenesis. 2013 Jun;34(6):1304-1314.
    2013-05-14 Phenanthroindolizidine analogues US8440649/2013-05-14
    2013-04-13 Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents FASEB Journal. 2013 Apr 13;27:lb71.
    2013-04 Tylophorine induces c-Jun protein accumulation through two discrete prolonged pathways NF-kappaB/PKCdelta/JNK and PI3K/PDK1/PP2A/eEF2 to promote G1 arrest in carcinoma cells FASEB Journal. 2013 Apr;27:lb74.
    2013-04 Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells FASEB Journal. 2013 Apr;27:lb70.
    2013-03 Cytotoxic cardenolide glycosides from the root of Reevesia formosana Phytochemistry. 2013 Mar;87:86-95.
    2012-12-13 Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity Journal of Medicinal Chemistry. 2012 Dec 13;55(23):10363-10377.
    2011-11 Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata Planta Medica. 2011 Nov;77(17):1932-1938.
    2011-01 Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238.
    2011-01 Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of ardisia cornudentata Planta Medica. 2011 Jan;77(1):60-65.
    2010-11 Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus Antiviral Research. 2010 Nov;88(2):160-168.
    2010-11 Cytotoxic Sesquiterpenes from Magnolia kachirachirai Chemistry and Biodiversity. 2010 Nov;7(11):2737-2747.

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