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    顯示項目1-50 / 67. (共2頁)
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    日期題名關聯
    2016-03 Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation MedChemComm. 2016 Mar;7(3):433-438.
    2014-06-09 EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PLoS ONE. 2014 Jun 9;9(6):Article number e92164.
    2014-02 Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum Journal of Biological Chemistry. 2014 Feb 14;289 (7):4444-4454.
    2014-02 Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation PLoS ONE. 2014 Feb 13;9(2):Article number e88772.
    2013-08 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum Journal of Biological Chemistry. 2013 Aug;288(35):25330-25339.
    2013-02-11 吡咯啶化合物 I385171/2013-02-11
    2012-01-17 Pyrrolidine compounds CA2559611/2012-01-17
    2011-12-06 Pyrrolidine compounds US8071787B2/2011-12-06
    2011-11-04 Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9 FEBS Letters. 2011 Nov 4;585(21):3409-3414.
    2011-09 Proline in transmembrane domain of type II protein DPP-IV governs Its translocation behavior through endoplasmic reticulum Biochemistry. 2011 Sep;50(37):7909-7918.
    2011-08 Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): Is DPP8-selectivity an attainable goal? Journal of Medicinal Chemistry. 2011 Aug;54(16):5737-5746.
    2011-06 Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate Journal of Biochemistry. 2011 Jun;149(6):685-692.
    2011-03 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum Journal of Cell Biology. 2011 Mar;192(5):825-838.
    2010-12-01 吲哚化合物 ZL200480034988.8/2010-12-01
    2010-12 Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV) International Journal of Biomedical Science. 2010 Dec;6(4):301-309.
    2010-10-06 吡咯烷化合物 ZL200580009891.6/2010-10-06
    2010-10 Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists ChemMedChem. 2010 Oct;5(10):1707-1716.
    2010-09 The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities Protein Science. 2010 Sep;19(9):1627-1638.
    2010-08 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583.
    2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
    2010-03-30 Pyrrolidine compounds US7687504B2/2010-03-30
    2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
    2009-09-03 Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis FEBS Letters. 2009 Sep 3;583(17):2765-2771.
    2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.
    2009-06 Enzyme Activity and Immunohistochemical Localization of Dipeptidyl Peptidase 8 and 9 in Male Reproductive Tissues Journal of Histochemistry and Cytochemistry. 2009 Jun;57(6):531-541.
    2009-06 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763.
    2009-05-15 Biochemical properties and expression profile of human prolyl dipeptidase DPP9 Archives of Biochemistry and Biophysics. 2009 May 15;485(2):120-127.
    2009-04-23 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622.
    2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
    2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
    2009-01-22 Pyrrolidine compounds AU2005221678/2009-01-22
    2009 Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme Antiviral Chemistry and Chemotherapy. 2009;19(4):151-156.
    2008-12-11 吲哚化合物 I304066/2008-12-11
    2008-11-11 Indole compounds US7449478B2/2008-11-11
    2008-08 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.
    2008-07-21 吡咯啉啶化合物 I299039/2008-07-21
    2008-07-15 Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4154-4158.
    2008-07-15 Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4159-4162.
    2008-07-01 Pyrrolidine compounds KR10-0844593/2008-07-01
    2008-05-01 Purification and characterization of a dipeptidyl peptidase 9-like enzyme from bovine testes Frontiers in Bioscience. 2008 May 1;13(9):3558-3568.
    2008-05 Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana Phytotherapy Research. 2008 May;22(5):605-613.
    2008-04-15 Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Biochemical Pharmacology. 2008 Apr;75(8):1601-1609.
    2008-04-06 COMP 266-Structure, function and inhibitors of prolyl dipeptidase DPP8 Abstracts of Papers - American Chemical Society. 2008 Apr 6;235:266-COMP.
    2007-11-15 Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates Journal of Medicinal Chemistry. 2007 Nov;50(23):5568-5570.
    2007-05 Dipeptidyl peptidase 8/9-like activity in human leukocytes Journal of Leukocyte Biology. 2007 May;81(5):1252-1257.
    2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279.
    2006-12-15 Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8 Journal of Biological Chemistry. 2006 Dec;281(50):38653-38662.
    2006-12 Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 Advances in Experimental Medicine and Biology. 2006 Dec;575:27-32.
    2006-10-19 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
    2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes Abstracts of Papers - American Chemical Society. 2006 Sep;232:MEDI 416.

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