國家衛生研究院 NHRI:
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    近3年内发表的文件:9(4.19%)
    含全文笔数:170(79.07%)

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    日期题名關聯
    2024-07-04 Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells Cells. 2024 Jul 04;13(13):Article number 1146.
    2024-04 Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice Biomedicine and Pharmacotherapy. 2024 Apr;173:Article number 116404.
    2023-10 Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs Annals of Oncology. 2023 Oct;34(Suppl. 2):S214.
    2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
    2022-10-13 Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824.
    2022-06-21 Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids Pharmaceutics. 2022 Jun 21;14(7):Article number 1316.
    2022-01-18 Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis mBio. 2022 Jan 18;13(1):Article number e0271721.
    2022-01-11 Extracellular HSP90alpha induces MyD88-IRAK complex-associated IKKalpha/Beta−NF-KappaB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization Cells. 2022 Jan 11;11(2):Article number 229.
    2022-01-05 The beneficial effects of combining anti-Abeta antibody NP106 and curcumin analog TML-6 on the treatment of Alzheimer’s disease in APP/PS1 mice International Journal of Molecular Sciences. 2022 Jan 5;23(1):Article number 556.
    2021-07-30 The effects of Abeta1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2 International Journal of Molecular Sciences. 2021 Jul 30;22(15):Article number 8226.
    2021-07-16 Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens Nanomaterials. 2021 Jul 16;11(7):Article number 1844.
    2021-01 Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro Antimicrobial Agents and Chemotherapy. 2021 Jan;65(1):Article number e00695-20.
    2020-12 Engineering a novel IgG-like bispecific antibody against enterovirus A71 Biochemistry and Biophysics Reports. 2020 Dec;24:Article number 100860.
    2020-08-20 Discovery of M protease inhibitors encoded by SARS-CoV-2 Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20.
    2020-08 Artificial intelligence approach fighting COVID-19 with repurposing drugs Biomedical Journal. 2020 Aug;43(4):355-362.
    2020-08 Repurposing old drugs as antiviral agents for coronaviruses Biomedical Journal. 2020 Aug;43(4):368-374.
    2020-06-02 Zika virus NS3 protease pharmacophore anchor model and drug discovery Scientific Reports. 2020 Jun 2;10:Article number 8929.
    2020-05 Antiviral activity of llama-inspired single domain antibody against Enterovirus A71 Antimicrobial Agents and Chemotherapy. 2020 May;64(5):Article number e01922-19.
    2020-05 Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors Bioorganic Chemistry. 2020 May;98:Article number 103689.
    2020-04 BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine Neuropharmacology. 2020 Apr;166:Article number 107678.
    2019-11-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
    2019-10 Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer Annals of Oncology. 2019 Oct;30(Suppl. 5):789.
    2019-10 Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117) Annals of Oncology. 2019 Oct;30(Suppl. 5):191.
    2019-07-11 Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062.
    2019-05-28 Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform Cancers. 2019 May 28;11(6):Article number 739.

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