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日期	题名	關聯
2024-09	Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy	APL Bioengineering. 2024 Sep;8:Article number 036107.
2023-08	Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks	eBioMedicine. 2023 Aug;Article number 104723.
2022-06	The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection	Journal of Biological Chemistry. 2022 Jun;298(6):Article number 101956.
2021-03-30	Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model	PLoS Pathogens. 2021 Mar 30;17(3):Article number e1009480.
2019-12	A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses	Antiviral Research. 2019 Dec;172:Article number 104636.
2019-08-27	A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication	Viruses. 2019 Aug 27;11(9):Article number 787.
2019-07	Nucleoside analogs with selective antiviral activity against dengue fever and Japanese encephalitis viruses	Antimicrobial Agents and Chemotherapy. 2019 Jul;63(7):e00397-19.
2019-04-01	A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus	European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
2019-03	Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A	Journal of General Virology. 2019 Mar;100(3):457-470.
2018-09	Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication	Journal of Virological Methods. 2018 Sep;259:10-17.
2018-07-26	The conserved stem-loop II structure at the 3' untranslated region of Japanese encephalitis virus genome is required for the formation of subgenomic flaviviral RNA	PLoS ONE. 2018 Jul 26;13(7):Article number e0201250.
2017-06	Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments	Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2015-06-01	治療C型肝炎病毒感染之醫藥組成物	I486160/2015-06-01
2015-04	Scanning mutagenesis studies reveal a potential intramolecular interaction within the C-Terminal half of Dengue Virus NS2A involved in viral RNA replication and virus assembly and secretion	Journal of Virology. 2015 Apr;89(8):4281-4295.
2014-07	A novel approach to propagate flavivirus infectious cDNA clones in bacteria by introducing tandem repeat sequences upstream of virus genome	Journal of General Virology. 2014 Jul;95(Pt 7):1493-1503.
2014-06-26	Baicalin, a metabolite of baicalein with antiviral activity against dengue virus	Scientific Reports. 2014 Jun 26;4:Article number 5452.
2014-01	A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease	Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
2013-05	Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus	Antiviral Research. 2013 May;98(2):228-241.
2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
2012-04-11	咪唑啉酮及咪唑啉硫酮衍生物	I361808/2012-04-11
2012-01	Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor	Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53.
2011-05-10	Imidazolidinone and imidazolidinethione derivatives	US7939523B2/2011-05-10
2011-04	Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952.
2011-03	Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes	Journal of Virology. 2011 Mar;85(6):2927-2941.
2011-01	Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay	Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238.
2010-09-01	Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors	Bioorganic and Medicinal Chemistry. 2010 Sep ;18(17):6414-6421.
2009-11-01	Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068.
2009-08-01	Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors	Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138.
2009-02	A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity	Microbes and Infection. 2009 Feb;11(2):288-295.
2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	Journal of Medicinal Chemistry. 2006 May;49(9):2703-2712.

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