國家衛生研究院 NHRI:
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    日期題名關聯
    2024-09 Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy APL Bioengineering. 2024 Sep;8:Article number 036107.
    2023-08 Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks eBioMedicine. 2023 Aug;Article number 104723.
    2022-06 The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection Journal of Biological Chemistry. 2022 Jun;298(6):Article number 101956.
    2021-03-30 Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model PLoS Pathogens. 2021 Mar 30;17(3):Article number e1009480.
    2019-12 A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses Antiviral Research. 2019 Dec;172:Article number 104636.
    2019-08-27 A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication Viruses. 2019 Aug 27;11(9):Article number 787.
    2019-07 Nucleoside analogs with selective antiviral activity against dengue fever and Japanese encephalitis viruses Antimicrobial Agents and Chemotherapy. 2019 Jul;63(7):e00397-19.
    2019-04-01 A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
    2019-03 Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A Journal of General Virology. 2019 Mar;100(3):457-470.
    2018-09 Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication Journal of Virological Methods. 2018 Sep;259:10-17.
    2018-07-26 The conserved stem-loop II structure at the 3' untranslated region of Japanese encephalitis virus genome is required for the formation of subgenomic flaviviral RNA PLoS ONE. 2018 Jul 26;13(7):Article number e0201250.
    2017-06 Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
    2017-01 A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
    2015-10 Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
    2015-06-01 治療C型肝炎病毒感染之醫藥組成物 I486160/2015-06-01
    2015-04 Scanning mutagenesis studies reveal a potential intramolecular interaction within the C-Terminal half of Dengue Virus NS2A involved in viral RNA replication and virus assembly and secretion Journal of Virology. 2015 Apr;89(8):4281-4295.
    2014-07 A novel approach to propagate flavivirus infectious cDNA clones in bacteria by introducing tandem repeat sequences upstream of virus genome Journal of General Virology. 2014 Jul;95(Pt 7):1493-1503.
    2014-06-26 Baicalin, a metabolite of baicalein with antiviral activity against dengue virus Scientific Reports. 2014 Jun 26;4:Article number 5452.
    2014-01 A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
    2013-05 Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus Antiviral Research. 2013 May;98(2):228-241.
    2013-02 Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
    2012-04-11 咪唑啉酮及咪唑啉硫酮衍生物 I361808/2012-04-11
    2012-01 Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53.
    2011-05-10 Imidazolidinone and imidazolidinethione derivatives US7939523B2/2011-05-10
    2011-04 Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952.

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