國家衛生研究院 NHRI:
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    Patents [0/19]
    Periodical Articles [47/47]
    Conference Papers/Meeting Abstract [6/8]

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    Showing items 1-25 of 74. (3 Page(s) Totally)
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    DateTitleRelation
    2024-11-26 Development of potent and selective inhibitors of methylenetetrahydrofolate dehydrogenase 2 for targeting acute myeloid leukemia: Sar, structural insights, and biological characterization Journal of Medicinal Chemistry. 2024 Nov 26;67(23):21106-21125.
    2022-02-05 Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
    2021-08-12 Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
    2020-02-10 Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
    2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
    2019-11-27 Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
    2019-10 Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer Annals of Oncology. 2019 Oct;30(Suppl. 5):789.
    2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
    2018-04 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy Bioorganic Chemistry. 2018 Apr;77:600-607.
    2017-06 Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
    2017-01-13 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors IN279196/2017-01-13
    2016-12 Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84.
    2016-11-23 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors EP2276346/2016-11-23
    2016-10-13 오로라 키나아제 저해제용 접합 2고리 피리미딘 화합물 KR10-1667822/2016-10-13
    2016-06-07 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors CA2722220/2016-06-07
    2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
    2016-01 Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1 Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
    2016-01 Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
    2015-10 Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
    2015-08-20 Fused bicyclic pyrimidine compounds as Aurora kinase inhibitors AU2009241469/2015-08-20
    2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 HK1151694/2015-07-31
    2015-04-28 作為極光激酶抑制劑的稠合雙環嘧啶化合物 J/001653/2015-04-28
    2014-10-29 作為極光激酶抑制劑的稠合雙環嘧啶化合物 ZL200980115577.4/2014-10-29
    2014-10-29 作为极光激酶抑制剂的稠合双环嘧啶化合物 CN102014627/2014-10-29
    2014-08 Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.

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