國家衛生研究院 NHRI:
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    显示项目151-175 / 212. (共9页)
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    日期题名關聯
    2010-06-15 Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988.
    2010-04-27 Oxadiazole compounds US7705024B2/2010-04-27
    2010-03-30 Pyrrolidine compounds US7687504B2/2010-03-30
    2010-03 Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents Journal of Medicinal Chemistry. 2010 Mar;53(6):2409-2417.
    2010-02-25 Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives Journal of Medicinal Chemistry. 2010 Feb 25;53(4):1519-1533.
    2010-02-23 Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity Journal of Biomedical Science. 2010 Feb 23;17:Article number 13.
    2010-02-01 Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor ChemMedChem. 2010 Feb 1;5(2):255-267.
    2010-02 Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 Pharmacological Research. 2010 Feb;61(2):108-115.
    2010-01 BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses Journal of Antimicrobial Chemotherapy. 2010 Jan;65(1):63-71.
    2009-11-01 Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068.
    2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
    2009-09 Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development EJC Supplements. 2009 Sep;7(2):96.
    2009-08-14 Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression Biochemical and Biophysical Research Communications. 2009 Aug 14;386(1):140-145.
    2009-08-01 Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138.
    2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
    2009-07-23 Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233.
    2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.
    2009-06-09 Treatment of coronavirus infection US7544712B1/2009-06-09
    2009-06 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763.
    2009-04-23 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622.
    2009-04-01 Design, synthesis, and anti-HCV activity of thiourea compounds Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955.
    2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
    2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
    2009-02-26 Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062.
    2009-02 Aurintricarboxylic acid inhibits influenza virus neuraminidase Antiviral Research. 2009 Feb;81(2):123-131.

    显示项目151-175 / 212. (共9页)
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