2010-06-15 |
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification |
Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988. |
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2010-04-27 |
Oxadiazole compounds |
US7705024B2/2010-04-27 |
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2010-03-30 |
Pyrrolidine compounds |
US7687504B2/2010-03-30 |
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2010-03 |
Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents |
Journal of Medicinal Chemistry. 2010 Mar;53(6):2409-2417. |
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2010-02-25 |
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives |
Journal of Medicinal Chemistry. 2010 Feb 25;53(4):1519-1533. |
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2010-02-23 |
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity |
Journal of Biomedical Science. 2010 Feb 23;17:Article number 13. |
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2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor |
ChemMedChem. 2010 Feb 1;5(2):255-267. |
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2010-02 |
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 |
Pharmacological Research. 2010 Feb;61(2):108-115. |
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2010-01 |
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses |
Journal of Antimicrobial Chemotherapy. 2010 Jan;65(1):63-71. |
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2009-11-01 |
Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068. |
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2009-10 |
(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases |
Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055. |
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2009-09 |
Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development |
EJC Supplements. 2009 Sep;7(2):96. |
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2009-08-14 |
Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression |
Biochemical and Biophysical Research Communications. 2009 Aug 14;386(1):140-145. |
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2009-08-01 |
Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138. |
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2009-07-23 |
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510. |
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2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
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2009-07-15 |
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor |
Biochemical Pharmacology. 2009 Jul 15;78(2):203-210. |
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2009-06-09 |
Treatment of coronavirus infection |
US7544712B1/2009-06-09 |
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2009-06 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] |
European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763. |
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2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
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2009-04-01 |
Design, synthesis, and anti-HCV activity of thiourea compounds |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955. |
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2009-04-01 |
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912. |
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2009-03-15 |
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399. |
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2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062. |
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2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase |
Antiviral Research. 2009 Feb;81(2):123-131. |
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