| 2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
Phytotherapy Research. 2008 May;22(5):605-613. |
 |
| 2008-04-15 |
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus |
Biochemical Pharmacology. 2008 Apr;75(8):1601-1609. |
|
| 2008-03-13 |
Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors |
Journal of Medicinal Chemistry. 2008 Mar;51(5):1464-1468. |
|
| 2008-03-10 |
Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent |
Tetrahedron. 2008 Mar;64(11):2586-2595. |
|
| 2008-03-01 |
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627. |
|
| 2008-02-07 |
First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol |
Organic Letters. 2008 Feb 7;10(3):449-452. |
|
| 2008-02 |
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells |
Anti-Cancer Drugs. 2008 Feb;19(2):151-158. |
|
| 2007-12 |
Strategies of development of antiviral agents directed against influenza virus replication |
Current Pharmaceutical Design. 2007 Dec;13(34):3531-3542. |
|
| 2007-09-06 |
4-and 5-aroylindoles as novel classes of potent antitubulin agents |
Journal of Medicinal Chemistry. 2007 Sep;50(18):4548-4552. |
|
| 2007-07-31 |
Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil |
British Journal of Cancer. 2007 Jul;97(3):334-344. |
|
| 2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049. |
|
| 2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279. |
|
| 2007-02-08 |
Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells |
Cancer Letters. 2007 Feb;246(1-2):237-252. |
|
| 2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
Journal of Chromatography B. 2007 Feb;846(1-2):162-168. |
|
| 2006-12 |
Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats |
Journal of Food and Drug Analysis. 2006 Dec;14(4):329-333. |
|
| 2006-11-16 |
7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents |
Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659. |
|
| 2006-10-19 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists |
Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424. |
|
| 2006-10 |
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents |
ChemMedChem. 2006 Oct;1(10):1106-1118. |
|
| 2006-08-24 |
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease |
Journal of Medicinal Chemistry. 2006 Aug;49(17):5154-5161. |
|
| 2006-07 |
Antiviral drug discovery against SARS-CoV |
Current Medicinal Chemistry. 2006 Jul;13(17):2003-2020. |
|
| 2006-06-15 |
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2006 Jun;16(12):3268-3272. |
|
| 2006-06-15 |
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies |
Journal of Medicinal Chemistry. 2006 Jun;49(12):3485-3495. |
|
| 2006-05-04 |
Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities |
Journal of Medicinal Chemistry. 2006 May;49(9):2703-2712. |
|
| 2006-05 |
Antitubulin agents for the treatment of cancer - a medicinal chemistry update |
Expert Opinion on Therapeutic Patents. 2006 May;16(5):647-691. |
|
| 2006-02-09 |
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies |
Journal of Medicinal Chemistry. 2006 Feb;49(3):1212-1216. |
|
| 2006-01-12 |
2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
Journal of Medicinal Chemistry. 2006 Jan;49(1):373-380. |
|
| 2006-01-01 |
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system |
Bioorganic and Medicinal Chemistry. 2006 Jan 1;14(1):83-91. |
|
| 2005-12-29 |
Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities |
Journal of Medicinal Chemistry. 2005 Dec;48(26):8194-8208. |
|
| 2005-05 |
Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells - Role of NF-kappa B |
Arteriosclerosis, Thrombosis, and Vascular Biology. 2005 May;25(5):963-969. |
|
| 2005-05 |
Pharmaceutical design of antimitotic agents based on combretastatins |
Current Pharmaceutical Design. 2005 May;11(13):1655-1677. |
|
| 2005 |
Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3) |
Evidence-based Complementary and Alternative Medicine. 2005;2:209-215. |
|
| 2004-09-10 |
Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV |
FEBS Letters. 2004 Sep;574(1-3):116-120. |
|
| 2004-08-12 |
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents |
Journal of Medicinal Chemistry. 2004 Aug;47(17):4247-4257. |
|
| 2004-07-15 |
A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells |
Biochemical Pharmacology. 2004 Jul;68(2):293-303. |
|
| 2004-07-01 |
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo |
Cancer Research. 2004 Jul;64(13):4621-4628. |
|
| 2004-07 |
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide |
Antimicrobial Agents and Chemotherapy. 2004 Jul;48(7):2693-2696. |
|
| 2004-05-20 |
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents |
Journal of Medicinal Chemistry. 2004 May;47(11):2897-2905. |
|
| 2003-12-01 |
Substituent effects on di-pi-methane and aza-di-pi-methane rearrangements of dibenzo[f,h]quinoxalinobarrelenes |
Tetrahedron Letters. 2003 Dec;44(49):8761-8764. |
|
| 2003-06-15 |
Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent |
Biochemical Pharmacology. 2003 Jun;65(12):2009-2019. |
|
| 2003-03-10 |
Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents (vol 13, pg 101, 2003) |
Bioorganic and Medicinal Chemistry Letters. 2003 Mar;13(5):977-977. |
|
| 2003-01-06 |
Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents |
Bioorganic and Medicinal Chemistry Letters. 2003 Jan;13(1):101-105. |
|
| 2002-06-06 |
Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents |
Journal of Medicinal Chemistry. 2002 Jun;45(12):2556-2562. |
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