國家衛生研究院 NHRI:
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    近3年内发表的文件:12(5.24%)
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    日期题名關聯
    2016-12 Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Oncotarget. 2016 Dec;7(52):86239-86256.
    2016-12 Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer Oncotarget. 2016 Dec;7(52):85917-85928.
    2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST Annals of Oncology. 2016 Dec;27(Suppl. 9):Meeting Abstract 2P.
    2016-11-29 Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design European Journal of Medicinal Chemistry. 2016 Nov 29;124:186-199.
    2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.
    2016-09 Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy Journal of Biological Chemistry. 2016 Sep;291(37):19299-19311.
    2016-07-28 Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors European Journal of Medicinal Chemistry. 2016 Jul 28;123:397-406.
    2016-05-19 Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses OncoTargets and Therapy. 2016 May 19;9:2961-2973.
    2016-02-26 Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development Scientific Reports. 2016 Feb 26;6:Article number 21662.
    2016-02-19 作為酪胺酸激酶抑制劑的稠合雙環及多環嘧啶化合物 HK1162509/2016-02-19
    2016-02-04 作爲酪胺酸激酶抑制劑的稠合雙環及多環嘧啶化合物 J/001914/2016-02-04
    2016-01-01 Bispecific antibody conjugated manganese-based magnetic engineered iron oxide for imaging of HER2/neu- and EGFR-expressing tumors Theranostics. 2016 Jan 1;6(1):118-130.
    2015-10 Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
    2015-08 Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia Abstracts of Papers of the American Chemical Society. 2015 Aug;250:Meeting Abstract 490.
    2015-08 Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors Abstracts of Papers of the American Chemical Society. 2015 Aug;250:Meeting Abstract 182.
    2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 HK1151694/2015-07-31
    2015-07-24 チロシンキナーゼ阻害剤としての融合2環および3環ピリミジン化合物 JP5781934/2015-07-24
    2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 CN102264745/2015-07-22
    2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
    2015-06-29 Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification Scientific Reports. 2015 Jun 29;5:Article number 11702.
    2015-06-16 Anchor-based classification and type-C inhibitors for tyrosine kinases Scientific Reports. 2015 Jun 16;5:Article number 10938.
    2015-01-02 KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity Journal of Biomedical Science. 2015 Jan 2;22:Article number 2.
    2015-01 Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity Journal of Computer-Aided Molecular Design. 2015 Jan;29(1):89-100.
    2014-12 BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71 Antiviral Research. 2014 Dec;112:18-25.
    2014-11-20 The combination effects of LiCl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication PLoS ONE. 2014 Nov 20;9(11):Article number e111331.

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