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Tylophorine induces c-Jun protein accumulation through two discrete prolonged pathways NF-kappaB/PKCdelta/JNK and PI3K/PDK1/PP2A/eEF2 to promote G1 arrest in carcinoma cells |
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Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells |
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Design and synthesis of Aurora kinase inhibitors as anticancer agents |
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MPT0G066, a novel microtubule-destabilizing agent, induces cell apoptosis and potentiates antineoplastic effects of cisplatin in human ovarian cancer cells in vitro and in vivo |
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Thiophene compounds |
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Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway |
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| 2013-03 |
Cytotoxic cardenolide glycosides from the root of Reevesia formosana |
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Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
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In vivo imaging of brain infarct with the novel fluorescent probe psvue 794 in a rat middle cerebral artery occlusion-reperfusion model |
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Use of novel species-specific PCR primers targeted to DNA gyrase subunit B (gyrB) gene for species identification of the Cronobacter sakazakii and Cronobacter dublinensis |
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3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor |
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An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold |
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Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors |
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HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy |
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Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo |
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Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching |
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Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors |
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DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells |
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Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species |
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58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway |
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Pyrrolidine derivatives |
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Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs |
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EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells |
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