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    显示项目1-50 / 1008. (共21页)
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    日期题名關聯
    2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
    2024-09 Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy APL Bioengineering. 2024 Sep;8:Article number 036107.
    2024-08-14 Induction of thymus atrophy and disruption of thymocyte development by fipronil through dysregulation of IL-7-associated genes Chemical Research in Toxicology. 2024 Aug 14;Article in Press.
    2024-08-02 A novel multitask learning algorithm for tasks with distinct chemical space: zebrafish toxicity prediction as an example Journal of Cheminformatics. 2024 Aug 02;16:Article number 91.
    2024-07-31 Incorporating tissue-specific gene expression data to improve chemical-disease inference of in silico toxicogenomics methods Journal of Xenobiotics. 2024 Jul 31;14(3):1023-1035.
    2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia Cell Chemical Biology. 2024 Jul 17;Article in Press.
    2024-07-04 Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells Cells. 2024 Jul 04;13(13):Article number 1146.
    2024-06-24 Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease European Polymer Journal. 2024 Jun 24;214:Article number 113151.
    2024-06-24 Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
    2024-06-01 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
    2024-05-28 Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis RSC Advances. 2024 May 28;14:17195-17201.
    2024-05-09 Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function Journal of Biomedical Science. 2024 May 09;31:Article number 46.
    2024-04 Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles Molecular Diversity. 2024 Apr;28(2):595-608.
    2024-04 BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir Antimicrobial Agents and Chemotherapy. 2024 Apr 3;68(4):Article number e0095623
    2024-04 Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice Biomedicine and Pharmacotherapy. 2024 Apr;173:Article number 116404.
    2024-03 Probing the hair detectability of prohibited substances in sports: An in vivo-in silico-clinical approach and analytical implications compared with plasma, urine, and faeces Archives of Toxicology. 2024 Mar;98(3):779-790.
    2024-03 Multitask learning for predicting pulmonary absorption of chemicals Food and Chemical Toxicology. 2024 Mar;185:Article number 114453.
    2024-03 Immunomodulatory and anti-angiogenesis effects of excavatolide B and its derivatives in alleviating atopic dermatitis Biomedicine and Pharmacotherapy. 2024 Mar;172:Article number 116279.
    2024-02-16 Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo ACS Food Science and Technology. 2024 Feb 16;4(2):479-490.
    2024-02-15 Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice Biochemical and Biophysical Research Communications. 2024 Feb 15;704:Article number 149668.
    2024-01-23 Decrypting orphan GPCR drug discovery via multitask learning Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
    2024-01-22 Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice BMC Veterinary Research. 2024 Jan 22;20:Article number 30.
    2024-01-10 Exploring the relationship between gut microbiome composition and blood indole-3-acetic acid in hemodialysis patients Biomedicines. 2024 Jan 10;12(1):Article number 148.
    2023-12 Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung Journal of Drug Delivery Science and Technology. 2023 Dec;90:Article number 105144.
    2023-11-15 Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors Bioorganic and Medicinal Chemistry. 2023 Nov 15;95:Article number 117502.
    2023-11-03 Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone Organic Letters. 2023 Nov 3;25(43):7757-7762.
    2023-11-01 MicroRNA regulators of vascular pathophysiology in chronic kidney disease Clinica Chimica Acta. 2023 Nov 1;551:Article number 117610.
    2023-11 Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death Pharmacological Research. 2023 Nov;197:Article number 106945.
    2023-10-26 Canine diffuse large b-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles Cancer Cell International. 2023 Oct 26;23:Article number 252.
    2023-10-05 Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115583.
    2023-10-05 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
    2023-10 16-Hydroxybriaranes from the octocoral Briareum stechei Phytochemistry Letters. 2023 Oct;57:92-95.
    2023-10 Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs Annals of Oncology. 2023 Oct;34(Suppl. 2):S214.
    2023-08 Machine learning for predicting chemical migration from food packaging materials to foods Food and Chemical Toxicology. 2023 Aug;178:Article number 113942.
    2023-08 Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks eBioMedicine. 2023 Aug;Article number 104723.
    2023-07-20 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
    2023-07-18 Marine diterpenoid targets STING palmitoylation in mammalian cells Communications Chemistry. 2023 Jul 18;6:Article number 153.
    2023-05-11 Induction of immune responses and phosphatidylserine exposure by TLR9 activation results in a cooperative antitumor effect with a phosphatidylserine-targeting prodrug International Journal of Biological Sciences. 2023 May 11;19(9):2648-2662.
    2023-03-28 Synthesis and structure–activity relationship of salvinal derivatives as potent microtubule inhibitors International Journal of Molecular Sciences. 2023 Mar 28;24(7):Article number 6386.
    2023-03-17 A convenient diels-alder approach toward potential polyketide-like antibiotics using alpha-activated alpha,Beta-unsaturated 4,4-dimethyl-1-tetralones as dienophiles Molecules. 2023 Mar 17;28(6):Article number 2739.
    2023-02-28 How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy Journal of Food and Drug Analysis. 2023 Feb 28;31(3):387-407.
    2023-02-13 Briavioid D, a rare 7Beta,8Beta-epoxybriarane from Briareum violaceum Tetrahedron Letters. 2023 Feb 13:Article number 154407.
    2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
    2023-02-06 Using random forest to predict antimicrobial minimum inhibitory concentrations of nontyphoidal Salmonella in Taiwan Veterinary Research. 2023 Feb 06;54(1):Article number 11.
    2023-02-03 MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition Journal of Experimental and Clinical Cancer Research. 2023 Feb 3;42:Article number 40.
    2023-01-19 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] Pharmaceutics. 2023 Jan 19;15(2):Article number 342.
    2023-01 Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson Natural Product Research. 2023 Jan;37(1):47-55.
    2023-01 Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
    2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
    2022-12-05 2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114773.

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