國家衛生研究院 NHRI:
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    近3年内发表的文件:19(12.50%)
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    显示项目126-150 / 152. (共7页)
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    日期题名關聯
    2010-09 Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist ChemMedChem. 2010 Sep;5(9):1439-1443.
    2010-08 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583.
    2010-07 Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 Anticancer Research. 2010 Jul;30(7):2813-2822.
    2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
    2010-02 Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 Pharmacological Research. 2010 Feb;61(2):108-115.
    2009-08-13 Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach Journal of Medicinal Chemistry. 2009 Aug 13;52(15):4941-4945.
    2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
    2009-07-15 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.
    2009-07 Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes Food and Chemical Toxicology. 2009 Jul;47(7):1703-1709.
    2009-04-17 Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents ChemMedChem. 2009 Apr 17;4(4):588-593.
    2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
    2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
    2009-02 Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: An in vitro and in vivo study Toxicological Sciences. 2009 Feb;107(2):385-393.
    2008-07-09 Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice International Journal of Pharmaceutics. 2008 Jul;359(1-2):174-181.
    2008-07 Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice Environmental Science and Technology. 2008 Jul;42(16):6264-6270.
    2008-05 High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine Phytochemical Analysis. 2008 May-Jun;19(3):258-265.
    2008-02-28 Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet Journal of Ethnopharmacology. 2008 Feb;116(1):49-57.
    2008-02 The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes Food and Chemical Toxicology. 2008 Feb;46(2):645-653.
    2007-10-01 Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry Journal of Chromatography B. 2007 Oct;857(2):195-201.
    2007-10 Differential effects of arsenic on cyp1 enzymes in vitro and in vivo Drug Metabolism Reviews. 2007 Oct;39(Suppl. 1):209.
    2007-09-15 Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry Journal of Chromatography B. 2007 Sep;857(1):164-169.
    2007-09 Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment Environmental Health Perspectives. 2007 Sep;115(9):1339-1343.
    2007-07 Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049.
    2007-02-01 Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study Journal of Chromatography B. 2007 Feb;846(1-2):162-168.
    2006-12 Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats Journal of Food and Drug Analysis. 2006 Dec;14(4):329-333.

    显示项目126-150 / 152. (共7页)
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