| 2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497. |
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| 2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
Life Sciences. 2021 Aug 1;278:Article number 119574. |
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| 2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins |
Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330. |
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| 2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment |
Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 30;118(13):Article number e2015433118. |
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| 2021-01 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors |
Chemical Biology and Drug Design. 2021 Jan;97(1):51-66. |
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| 2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Translational Oncology. 2021 Jan;14(1):Article number 100897. |
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| 2021-01 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease |
European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938. |
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| 2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
Biomedical Journal. 2020 Aug;43(4):355-362. |
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| 2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
Biomedical Journal. 2020 Aug;43(4):368-374. |
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| 2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification |
Cancer Research. 2020 Aug;80(16):1937. |
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| 2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
Bioorganic Chemistry. 2020 May;98:Article number 103689. |
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| 2020-04 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine |
Neuropharmacology. 2020 Apr;166:Article number 107678. |
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| 2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system |
Scientific Reports. 2020 Feb 18;10:Article number 2838. |
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| 2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors |
Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659. |
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| 2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment |
European Journal of Medicinal Chemistry. 2020 Feb 1;187:Article number 111915. |
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| 2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150. |
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| 2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
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| 2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
Annals of Oncology. 2019 Oct;30(Suppl. 5):789. |
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| 2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates |
Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062. |
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| 2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 227. |
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| 2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 3851. |
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| 2019-06-05 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice |
European Journal of Pharmacology. 2019 Jun 5;852:265-273. |
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| 2019-05 |
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents |
Future Medicinal Chemistry. 2019 May;11(9):959-974. |
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| 2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants |
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957. |
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| 2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268. |
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