國家衛生研究院 NHRI:
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    最後更新時間: 2025-02-26 09:49

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    日期題名關聯
    2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
    2015-01 1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells European Journal of Medicinal Chemistry. 2015 Jan;89:320-330.
    2014-11-19 咪唑-4-酮及咪唑-4-硫酮化合物 CN101723937/2014-11-19
    2014-11 Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent European Journal of Cancer. 2014 Nov;50(Suppl. 6):92-93.
    2014-10 Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma Cancer Research. 2014 Oct;74(19 Suppl.):Abstract No. 1756.
    2014-08-15 Anticancer oral formulation JP5596680/2014-08-15
    2014-06-04 抗癌口服制剂 CN102159541/2014-06-04
    2014-05 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells Journal of Medicinal Chemistry. 2014 May;57(10):4009-4022.
    2014-04-21 咪唑-4-酮及咪唑-4-硫酮化合物 TWI434686/2014-04-21
    2014-04 Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones European Journal of Medicinal Chemistry. 2014 Apr 22;77(2):306-314.
    2014-03 DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study Abstracts of Papers - American Chemical Society. 2014 Mar;247:Article number 315-MEDI.
    2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer PLoS ONE. 2014 Jan 8;9(1):Article number e83160.
    2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
    2013-11 BPR0C305, an orally active microtubule-disrupting anticancer agent Anticancer Drugs. 2013 Nov;24(10):1047-1057.
    2013-11 A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 Journal of Thoracic Oncology. 2013 Nov;8(Suppl. 2):S779-S780.
    2013-07-08 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors ChemBioChem. 2013 Jul 8;14(10):1248-1254.
    2013-07-08 Inside Cover: 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors(ChemBioChem 10/2013) ChemBioChem. 2013 Jul 8;14(10):1150.
    2013-07 CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions Pharmacogenomics. 2013 Jul;14(10):1191-1201.
    2013-06-05 Anticancer oral formulation EP2310363/2013-06-05
    2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867.
    2013-04-13 Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents FASEB Journal. 2013 Apr 13;27:lb71.
    2013-04-07 BPR000K, a novel Aurora kinase inhibitor Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 300-MEDI.
    2013-04-07 3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 87-MEDI.
    2013-04-07 Development drug candidate targeting EGFR kinase: DBPR112 Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 299-MEDI.
    2013-02-11 抗癌口服藥學組成物 TWI384984/2013-02-11

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