國家衛生研究院 NHRI:
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    Patents [0/7]
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    Showing items 26-40 of 40. (2 Page(s) Totally)
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    DateTitleRelation
    2012-07-04 噻吩化合物 ZL200780036897.1/2012-07-04
    2012-07 Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors International Journal of Obesity. 2012 Jul;36(7):999-1006.
    2011-10-01 硒吩化合物及其醫藥組成物 I349668/2011-10-01
    2011-06 A new perspective of cannabinoid 1 receptor antagonists: Approaches toward peripheral CB1R blockers without crossing the blood-brain barrier Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1421-1429.
    2011-03-21 吡唑化合物及其醫藥組成物 I339205/2011-03-21
    2011-01-13 Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178.
    2010-11-16 Thiophene compounds US7834046B2/2010-11-16
    2010-10 Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities Pharmacological Research. 2010 Oct;62(4):337-343.
    2010-09-28 Selenophene compounds US7803799B2/2010-09-28
    2010-09 Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist ChemMedChem. 2010 Sep;5(9):1439-1443.
    2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
    2009-02-01 1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists Bioorganic and Medicinal Chemistry Letters. 2009 Feb 1;19(3):1022-1025.
    2008-09-21 Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407.
    2008-09-11 Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412.
    2008-02-07 Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450.

    Showing items 26-40 of 40. (2 Page(s) Totally)
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