國家衛生研究院 NHRI:
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    Patents [0/7]
    Periodical Articles [28/29]
    Conference Papers/Meeting Abstract [3/4]

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    Showing items 1-25 of 40. (2 Page(s) Totally)
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    DateTitleRelation
    2024-01-23 Decrypting orphan GPCR drug discovery via multitask learning Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
    2023-07-20 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
    2023-01 Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
    2022-02-05 Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
    2020-02-10 Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
    2019-10 In vivo efficacy of cannabinoid receptor 1 antagonist, CPD1, in treating non-alcoholic fatty liver disease Hepatology. 2019 Oct;70:1333A.
    2019-08 A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes Biochemical Pharmacology. 2019 Aug;166:203-211.
    2019-01-01 Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
    2018-10-06 Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov;115(45):E10720-E10729.
    2018-08-21 DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 21;115(34):E8027-E8036.
    2018-07 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664.
    2018-04 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy Bioorganic Chemistry. 2018 Apr;77:600-607.
    2017-11 Caveolin-1 secreted from adipose tissues and adipocytes functions as an adipogenesis enhancer Obesity. 2017 Nov;25(11):1932-1940.
    2016-12 Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84.
    2016-07-22 Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons Nature Communications. 2016 Jul 22;7:Article number 12199.
    2016-01 Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1 Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
    2016-01 Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
    2015-10 Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
    2015-05 A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
    2014-08 Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
    2014-08 A novel mechanism for acupuncture-induced analgesia: involvement of orexins and endocannabinoids Journal of Neurochemistry. 2014 Aug;130(Suppl. s1):38.
    2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
    2013-09-11 噻吩化合物及其醫藥組成物 I408136/2013-09-11
    2013-05 Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines Journal of Immunology. 2013 May;190(10):5065-5077.
    2013-03-27 Thiophene compounds EP2068870/2013-03-27

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