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日期	題名	關聯
2024-01-23	Decrypting orphan GPCR drug discovery via multitask learning	Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
2023-07-20	Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin	Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
2023-01	Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists	Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-10	In vivo efficacy of cannabinoid receptor 1 antagonist, CPD1, in treating non-alcoholic fatty liver disease	Hepatology. 2019 Oct;70:1333A.
2019-08	A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes	Biochemical Pharmacology. 2019 Aug;166:203-211.
2019-01-01	Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist	Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
2018-10-06	Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray	Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov;115(45):E10720-E10729.
2018-08-21	DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation	Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 21;115(34):E8027-E8036.
2018-07	4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo	Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-11	Caveolin-1 secreted from adipose tissues and adipocytes functions as an adipogenesis enhancer	Obesity. 2017 Nov;25(11):1932-1940.
2016-12	Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy	European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84.
2016-07-22	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons	Nature Communications. 2016 Jul 22;7:Article number 12199.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2015-05	A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis	Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
2014-08	A novel mechanism for acupuncture-induced analgesia: involvement of orexins and endocannabinoids	Journal of Neurochemistry. 2014 Aug;130(Suppl. s1):38.
2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
2013-09-11	噻吩化合物及其醫藥組成物	I408136/2013-09-11
2013-05	Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines	Journal of Immunology. 2013 May;190(10):5065-5077.
2013-03-27	Thiophene compounds	EP2068870/2013-03-27

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