國家衛生研究院 NHRI:
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    显示项目1-25 / 212. (共9页)
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    日期题名關聯
    2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
    2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Life Sciences. 2021 Aug 1;278:Article number 119574.
    2021-01 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy Translational Oncology. 2021 Jan;14(1):Article number 100897.
    2019-07 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 227.
    2019-04-01 A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
    2019-04-01 The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
    2019-03 Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors Bioorganic Chemistry. 2019 Mar;83:520-525.
    2018-04 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy Bioorganic Chemistry. 2018 Apr;77:600-607.
    2018-01-01 Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620.
    2017-06-22 Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity Scientific Reports. 2017 Jun 22;7:Article number 4105.
    2017-01 A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
    2016-05 N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250.
    2016-01 Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
    2015-07-31 作為極光激酶抑制劑的稠合雙環嘧啶化合物 HK1151694/2015-07-31
    2015-07-29 脯氨酸衍生物 ZL201080002506.6/2015-07-29
    2015-07-22 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 ZL200980144458.1/2015-07-22
    2015-07 Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors European Journal of Pharmaceutical Sciences. 2015 Jul;74:40-44.
    2015-07 Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells Molecular and Cellular Biology. 2015 Jul;35(14):2541-2553.
    2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
    2015-06-01 治療C型肝炎病毒感染之醫藥組成物 I486160/2015-06-01
    2015-05-29 Proline derivatives JP5753185/2015-05-29
    2015-05 A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
    2015-04-14 Fused multicyclic compounds as protein kinase inhibitors US9006252B2/2015-04-14
    2015-02-24 Pyrazole compounds US8962845/2015-02-24
    2015-02-11 吡唑類化合物 I472514/2015-02-11

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