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Showing items 1-43 of 43. (1 Page(s) Totally) 1  View [10|25|50] records per page

Date	Title	Relation
2024-12	Alkoxylation of ketone mediated by N-heterocyclic carbene borane and sulfuric acid in alcohol	Asian Journal of Organic Chemistry. 2024 Dec;13(12):Article number e202400436.
2024-11-21	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	Cell Chemical Biology. 2024 Nov 21;31(11):1885-1898.e10.
2024-11	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790.
2024-05-01	Thiazolidinone compounds and use thereof	EP3426246/2024-05-01
2023-11-15	Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors	Bioorganic and Medicinal Chemistry. 2023 Nov 15;95:Article number 117502.
2023-10-05	A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects	European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-11-22	オピオイド受容体調節因子及びその使用	JP7181536/2022-11-22
2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2022-08-30	チアゾリジノン化合物及びその使用	JP7132849/2022-08-30
2022-05-20	噻唑烷酮化合物及其用途	HK1258687/2022-05-20
2022-03-08	Opioid receptor modulators and use thereof	CA2996281/2022-03-08
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2022-01-19	噻唑烷酮化合物及其用途	J/005474/2022-01-19
2022-01-05	阿片受體調節劑及其用途	J/005174/2022-01-05
2021-09-28	噻唑烷酮化合物及其用途	CN108883099/2021-09-28
2021-09-24	阿片受體調節劑及其用途	HK1253294/2021-09-24
2021-07-22	Thiazolidinone compounds and use thereof	AU2017229129/2021-07-22
2021-06-04	阿片受体调节剂及其用途	CN108369222/2021-06-04
2020-11-18	Opioid receptor modulators and use thereof	EP3344997/2020-11-18
2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	Scientific Reports. 2020 Oct 8;10:Article number 16771.
2020-04-21	噻唑烷酮化合物及其用途	TWI691332/2020-04-21
2020-04	BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine	Neuropharmacology. 2020 Apr;166:Article number 107678.
2020-03-24	Tetrahydroisoquinolines for use as MOR/NOP dual agonists	US10597378/2020-03-24
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2020-01-28	Thiazolidinone compounds and use thereof	US10544113/2020-01-28
2019-07	Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216	Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626.
2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
2019-02-20	Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice	Scientific Reports. 2019 Feb 20;9:Article number 2405.
2019-02-11	雜環化合物及其用途	TWI650313/2019-02-11
2018-07	4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo	Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664.
2018-06-01	鴉片受體調節劑及其用途	TWI625120/2018-06-01
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-11-28	Opioid receptor modulators and use thereof	US9827228/2017-11-28
2017-05	1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine	Anesthesiology. 2017 May;126(5):952-966.
2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	European Journal of Medicinal Chemistry. 2017 Jan;126:202-217.
2016-12	Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy	European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2014-09	Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists	Bioorganic and Medicinal Chemistry. 2014 Sep;22(17): 4694-4703.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
2012-08	Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching	Analytical Chemistry. 2012 Aug;84(15):6391-6399.

Showing items 1-43 of 43. (1 Page(s) Totally) 1  View [10|25|50] records per page