國家衛生研究院 NHRI:
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    Conference Papers/Meeting Abstract [5/9]
    Periodical Articles [30/30]

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    Showing items 1-10 of 39. (4 Page(s) Totally)
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    DateTitleRelation
    2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
    2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia Cell Chemical Biology. 2024 Jul 17;Article in Press.
    2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
    2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
    2022-02-05 Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
    2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
    2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
    2021-01 BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy Translational Oncology. 2021 Jan;14(1):Article number 100897.
    2020-10-08 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery Scientific Reports. 2020 Oct 8;10:Article number 16771.
    2020-08 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification Cancer Research. 2020 Aug;80(16):1937.

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