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顯示項目1-50 / 52. (共2頁) 1 2 > >> 每頁顯示[10|25|50]項目

日期	題名	關聯
2022-08	Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3beta and phosphorylated AKT expression levels	Journal of Microbiology, Immunology, and Infection. 2022 Aug;55(4):598-610.
2020-12	Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors	Emerging Microbes and Infections. 2020 Dec;9(1):1194-1205.
2019-12	A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses	Antiviral Research. 2019 Dec;172:Article number 104636.
2019-04-01	A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus	European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
2018-09	Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication	Journal of Virological Methods. 2018 Sep;259:10-17.
2017-12	Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels	Journal of Cellular Physiology. 2017 Dec;232(12):3409-3421.
2017-06	Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments	Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
2016-07	In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71	Journal of Antimicrobial Chemotherapy. 2016 Jul;71(7):1922-1932.
2015-07-29	脯氨酸衍生物	ZL201080002506.6/2015-07-29
2015-05-29	Proline derivatives	JP5753185/2015-05-29
2014-09-01	治療阿茲海默症或帕金森氏症之醫藥組成物	I450716/2014-09-01
2014-03-11	脯胺酸衍生物	I429645/2014-03-11
2014-01	A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease	Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
2013-04-09	Proline derivatives	US8415482B2/2013-04-09
2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
2012-06-12	Treatment of neurodegenerative disorders with thiourea compounds	US8198284B2/2012-06-12
2012-04-11	咪唑啉酮及咪唑啉硫酮衍生物	I361808/2012-04-11
2012-03-01	C型肝炎病毒抑制劑	I359137/2012-03-01
2012-01	Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor	Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53.
2011-07-26	Hepatitis C virus inhibitors	US7985763B2/2011-07-26
2011-05-10	Imidazolidinone and imidazolidinethione derivatives	US7939523B2/2011-05-10
2011-04	Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer	Investigational New Drugs. 2011 Apr;29(2):195-206.
2011-04	Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952.
2011-03-01	Thiourea derivatives	US7897764B2/2011-03-01
2011-01	Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay	Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238.
2011-01	BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities	Cancer Science. 2011 Jan;102(1):182-191.
2010-10	Modulation of microglial immune responses by a novel thiourea derivative	Chemico-Biological Interactions. 2010 Oct;188(1):228-236.
2010-09-01	Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors	Bioorganic and Medicinal Chemistry. 2010 Sep ;18(17):6414-6421.
2010-08-21	硫尿化合物及抑制C型肝炎病毒感染之方法	I329102/2010-08-21
2010-05-11	咪唑啉酮化合物	I324594/2010-05-11
2009-11-01	Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068.
2009-08-01	Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors	Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138.
2009-07	Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71	Antimicrobial Agents and Chemotherapy. 2009 Jul;53(7):2740-2747.
2009-04-01	Design, synthesis, and anti-HCV activity of thiourea compounds	Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955.
2009-03-10	Imidazolidinone compounds	US7501445B2/2009-03-10
2008-10-15	Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma	Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5676-5679.
2008-05	Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants	Journal of Biomedical Science. 2008 May;15(3):291-300.
2007-08-21	Imidazolidinone compounds	US7259174B2/2007-08-21
2007-06-01	咪唑啉酮化合物	I281919/2007-06-01
2006-10-31	Imidazolidinone compounds	US7129359B2/2006-10-31
2006-08-01	抗腸病毒化合物	I259083/2006-08-01
2005-10-01	Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4 '-chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one	Bioorganic and Medicinal Chemistry Letters. 2005 Oct;15(19):4206-4211.
2005-05-19	Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives	Journal of Medicinal Chemistry. 2005 May;48(10):3522-3535.
2004-11-09	Anti-enterovirus compounds	US6815444B2/2004-11-09
2004-10-18	Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones	Bioorganic and Medicinal Chemistry Letters. 2004 Oct;14(20):5051-5056.
2004-09	Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone	Antimicrobial Agents and Chemotherapy. 2004 Sep;48(9):3523-3529.
2004-06-01	咪唑啉酮化合物	203254/2004-06-01
2004-05-17	Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidinies: a novel class of potent enterovirus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2004 May;14(10):2519-2525.
2004-03-16	Imidazolidinone compounds	US6706739B2/2004-03-16

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