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Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells |
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2024-04-03 |
抗-乙型澱粉樣蛋白抗體及其用途 |
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2024-04 |
Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice |
Biomedicine and Pharmacotherapy. 2024 Apr;173:Article number 116404. |
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2024-01-26 |
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2023-12-08 |
抗-乙型淀粉样蛋白抗体及其用途 |
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2023-10-27 |
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2023-10-20 |
抗RSPO3抗体 |
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2023-10-12 |
Anti-abeta antibodies and uses thereof |
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2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs |
Annals of Oncology. 2023 Oct;34(Suppl. 2):S214. |
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2023-08-29 |
Anti-abeta antibodies and uses thereof |
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2023-06-21 |
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2023-04-18 |
항-A베타 항체 및 이의 용도 |
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2023-04-11 |
Antibodies to R-spondin 3 |
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2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588. |
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2023-01-13 |
抗Aベータ抗体及びその使用 |
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2022-10-13 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate |
Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824. |
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2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids |
Pharmaceutics. 2022 Jun 21;14(7):Article number 1316. |
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2022-01-18 |
Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis |
mBio. 2022 Jan 18;13(1):Article number e0271721. |
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2022-01-11 |
Extracellular HSP90alpha induces MyD88-IRAK complex-associated IKKalpha/Beta−NF-KappaB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization |
Cells. 2022 Jan 11;11(2):Article number 229. |
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2022-01-05 |
The beneficial effects of combining anti-Abeta antibody NP106 and curcumin analog TML-6 on the treatment of Alzheimer’s disease in APP/PS1 mice |
International Journal of Molecular Sciences. 2022 Jan 5;23(1):Article number 556. |
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2021-08-10 |
Anti-Abeta antibodies and uses thereof |
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2021-07-30 |
The effects of Abeta1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2 |
International Journal of Molecular Sciences. 2021 Jul 30;22(15):Article number 8226. |
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2021-07-16 |
Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens |
Nanomaterials. 2021 Jul 16;11(7):Article number 1844. |
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2021-03-11 |
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2021-01 |
Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro |
Antimicrobial Agents and Chemotherapy. 2021 Jan;65(1):Article number e00695-20. |
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2020-12 |
Engineering a novel IgG-like bispecific antibody against enterovirus A71 |
Biochemistry and Biophysics Reports. 2020 Dec;24:Article number 100860. |
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2020-08-21 |
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2020-08-20 |
Discovery of M protease inhibitors encoded by SARS-CoV-2 |
Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20. |
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2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
Biomedical Journal. 2020 Aug;43(4):355-362. |
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2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
Biomedical Journal. 2020 Aug;43(4):368-374. |
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2020-06-02 |
Zika virus NS3 protease pharmacophore anchor model and drug discovery |
Scientific Reports. 2020 Jun 2;10:Article number 8929. |
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2020-05 |
Antiviral activity of llama-inspired single domain antibody against Enterovirus A71 |
Antimicrobial Agents and Chemotherapy. 2020 May;64(5):Article number e01922-19. |
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2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
Bioorganic Chemistry. 2020 May;98:Article number 103689. |
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2020-04 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine |
Neuropharmacology. 2020 Apr;166:Article number 107678. |
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2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
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2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
Annals of Oncology. 2019 Oct;30(Suppl. 5):789. |
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2019-10 |
Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117) |
Annals of Oncology. 2019 Oct;30(Suppl. 5):191. |
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2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates |
Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062. |
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2019-05-28 |
Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform |
Cancers. 2019 May 28;11(6):Article number 739. |
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2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268. |
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2019-02-20 |
Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice |
Scientific Reports. 2019 Feb 20;9:Article number 2405. |
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2018-12 |
Dendritic cell-derived exosomes increase the efficacy of anti-PD-L1 antibody in melanoma model |
Cancer Science. 2018 Dec;109(Suppl. 2):1322. |
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2018-12 |
Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer |
Cancer Science. 2018 Dec;109(SI, Suppl. 2):210. |
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2018-12 |
Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer |
Cancer Science. 2018 Dec;109(Suppl. 2, SI):1257. |
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2018-10 |
Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach |
EBioMedicine. 2018 Oct;36:241-251. |
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2018-08-24 |
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor |
Cancer Science. 2018 Nov;109(11):3591-3601. |
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2018-07 |
Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer |
Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 4789. |
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2018-01-23 |
Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity |
Journal of Biomedical Science. 2018 Jan 23;25:Article number 6. |
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2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer |
Cancer Science. 2018 Jan;109(Suppl. 1):739. |
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2017-09-26 |
Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains |
Scientific Reports. 2017 Sep 26;7:Article number 12336. |
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