| 2012-07 |
Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors |
International Journal of Obesity. 2012 Jul;36(7):999-1006. |
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| 2012-07 |
K2CO3/NaI-induced cyclization of omega-bromo alpha-cyano ketones: A new annulation approach for the formation of carbalkoxycyclohexane ring system |
Synlett. 2012 Jul;23(11):1653-1656. |
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| 2012-05 |
Palladium(II) acetate mediated oxidative cyclization of omega-unsaturated alpha-cyano ketones for facile construction of methylenecyclohexane ring system |
Organic & Biomolecular Chemistry. 2012 May;10(23):4609-4617. |
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| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
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| 2011-10-01 |
硒吩化合物及其醫藥組成物 |
I349668/2011-10-01 |
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| 2011-08-11 |
噁二唑化合物 |
I346662/2011-08-11 |
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| 2011-07 |
Conia-ene annulation of the alpha-cyano Beta-TMS-capped alkynyl cycloalkanone system and its synthetic application |
Organic and Biomolecular Chemistry. 2011 Jul;9(13):4778-4781. |
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| 2011-06 |
Hot topic: Opportunities and potential challenges for the treatment of metabolic syndrome |
Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1420. |
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| 2011-03-21 |
吡唑化合物及其醫藥組成物 |
I339205/2011-03-21 |
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| 2011-03-04 |
Autoxidative annulation cascade of the alpha-cyano beta-TMS-capped alkynyl cycloalkanone system |
Organic Letters. 2011 Mar 4;13(5):896-899. |
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| 2010-11-16 |
Thiophene compounds |
US7834046B2/2010-11-16 |
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| 2010-10 |
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities |
Pharmacological Research. 2010 Oct;62(4):337-343. |
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| 2010-09-28 |
Selenophene compounds |
US7803799B2/2010-09-28 |
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| 2010-09 |
Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist |
ChemMedChem. 2010 Sep;5(9):1439-1443. |
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| 2010-08 |
Total synthesis of (-)-Isopisiferin: Confirmation of absolute configuration |
Journal of Organic Chemistry. 2010 Aug;2010(22):4271-4275. |
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| 2010-06 |
General approach to 2,3-dibenzyl-gamma-butyrolactone lignans: application to the total synthesis of (+/-)-5 '-methoxyyatein, (+/-)-5 '-methoxyclusin, and (+/-)-4 '-hydroxycubebinone |
European Journal of Organic Chemistry. 2010 Jun;2010(18):3473-3480. |
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| 2010-04-27 |
Oxadiazole compounds |
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| 2010-02 |
Alpha-activated cross conjugated cycloalkenone systems in organic synthesis |
Current Organic Synthesis. 2010 Feb;7(1):78-93. |
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| 2009-07-23 |
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510. |
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| 2009-04-16 |
Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy cyclohexenone system. An unusual 1,2-hydride shift under lewis acid catalysis |
Organic Letters. 2009 Apr 16;11(8):1673-1675. |
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| 2009 |
A concise total synthesis of (±)-acutifolone A |
Organic and Biomolecular Chemistry. 2009;7(16):3285-3290. |
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| 2008-09-21 |
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407. |
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| 2008-09-11 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists |
Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412. |
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| 2008-03 |
流感抗病毒藥物介紹 |
認識H5N1新型流感. 2008 Mar:41-46. |
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| 2008-02-07 |
Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists |
Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450. |
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| 2008-01-03 |
Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy enone system. Observation on a putative 1,5-hydride/1,3-alkyl shift under Lewis acid catalysis |
Organic Letters. 2008 Jan;10(1):121-123. |
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| 2007-05-16 |
Lithium naphthalenide induced reductive selenenylation of alpha-cyano ketones: A regiocontrolled process for alpha-phenylseleno ketones and one-pot conversion into enone system |
Synlett. 2007 May(8):1274-1278. |
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| 2007-05-16 |
An efficient new procedure for the one-pot conversion of aldehydes into the corresponding nitriles |
Synlett. 2007 May(8):1317-1319. |
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| 2007-03 |
First total synthesis of the cis-clerodane diterpenoids solidagolactones IV and V |
Abstracts of Papers - American Chemical Society. 2007 Mar;233:407-ORGN. |
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| 2007 |
A convenient new procedure for converting primary amides into nitriles |
Chemical Communications. 2007 (3):301-303. |
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| 2006-08-01 |
抗腸病毒化合物 |
I259083/2006-08-01 |
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| 2005-04 |
Carbapenern-based prodrugs. Design, synthesis, and biological evaluation of carbapenems |
European Journal of Medicinal Chemistry. 2005 Apr;40(4):339-349. |
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| 2005 |
Design, synthesis and biological evaluation of novel carbapenems |
International Journal of Scientific Research. 2005;14:59-70 |
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| 2004-11-09 |
Anti-enterovirus compounds |
US6815444B2/2004-11-09 |
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| 2004-10-18 |
Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones |
Bioorganic and Medicinal Chemistry Letters. 2004 Oct;14(20):5051-5056. |
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| 2004-09 |
Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone |
Antimicrobial Agents and Chemotherapy. 2004 Sep;48(9):3523-3529. |
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| 2004-06-01 |
咪唑啉酮化合物 |
203254/2004-06-01 |
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| 2004-05-17 |
Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidinies: a novel class of potent enterovirus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2004 May;14(10):2519-2525. |
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| 2004-03-16 |
Imidazolidinone compounds |
US6706739B2/2004-03-16 |
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| 2004-03-08 |
Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives |
Bioorganic and Medicinal Chemistry Letters. 2004 Mar;14(5):1169-1172. |
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| 2003-02-17 |
A modified Robinson annulation process to alpha,alpha-disubstituted-beta,gamma-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal |
Tetrahedron. 2003 Feb;59(8):1209-1226. |
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| 2002-10-07 |
Synthesis and anticancer evaluation of vitamin K-3 analogues |
Bioorganic and Medicinal Chemistry Letters. 2002 Oct;12(19):2729-2732. |
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| 2002-08 |
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors |
Abstracts of Papers of the American Chemical Society. 2002 Aug;224(Part 2):U10-U11. |
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| 2002-04-11 |
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors |
Journal of Medicinal Chemistry. 2002 Apr;45(8):1644-1655. |
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| 2002 |
Diels-Alder chemistry of 2-diethoxyphosphinylcyclohex-2-enones. A new approach to complex phosphonates and synthetic applications of the beta-keto phosphonate system |
Chemical Communications. 2002(3):248-249. |
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| 2001-11 |
An efficacious synthetic strategy for cis-clerodane diterpenoids. Application to the total synthesis of (+/-)-6 beta-acetoxy-2-oxokolavenool |
Synlett. 2001 Nov(11):1805-1807. |
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| 2001-04 |
Improved general synthetic approach to cis-clerodane diterpenoids: A more efficient total synthesis of (+/-)-6 beta-acetoxy-2-oxokolavenool |
Abstracts of Papers of the American Chemical Society. 2001 Apr;221:U184. |
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| 1999-06 |
Polyene cyclization promoted by the cross conjugated alpha-carbalkoxy enone system. An efficient approach to highly functionalized decalins |
Journal of the Chinese Chemical Society. 1999 Jun;46(3):453-462. |
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