| 2012-02 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents |
Investigational New Drugs. 2012 Feb;30(1):164-175. |
 |
| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
|
| 2012-01-17 |
Pyrrolidine compounds |
CA2559611/2012-01-17 |
|
| 2012-01 |
Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor |
Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53. |
|
| 2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
British Journal of Cancer. 2012 Jan;106(3):475-481. |
|
| 2012-01 |
A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors |
Anticancer Research. 2012 Jan;32(1):147-151. |
|
| 2011-11-15 |
Coumarin compounds and their use for treating cancer |
US8058427B2/2011-11-15 |
|
| 2011-11 |
Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata |
Planta Medica. 2011 Nov;77(17):1932-1938. |
|
| 2011-10-01 |
硒吩化合物及其醫藥組成物 |
I349668/2011-10-01 |
|
| 2011-09-27 |
Formulations of indol-3-yl-2-oxoacetamide compounds |
US8026271B2/2011-09-27 |
|
| 2011-09-23 |
BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo |
European Journal of Cancer. 2011 Sep 23;47:S127. |
|
| 2011-09-20 |
Pyrrolidine derivatives |
US8022096B2/2011-09-20. |
|
| 2011-09 |
Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway |
Journal of Virology. 2011 Sep;85(17):9114-9126 |
|
| 2011-09 |
Overcoming the acquired resistance to Afatinib (BIBW2992) in HCC827, a non-small cell lung cancer cell line |
European Journal of Cancer. 2011 Sep;47:S129. |
|
| 2011-08-11 |
噁二唑化合物 |
I346662/2011-08-11 |
|
| 2011-07-26 |
Hepatitis C virus inhibitors |
US7985763B2/2011-07-26 |
|
| 2011-07-25 |
The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside |
Chemistry-A European Journal. 2011 Jul 25;17(31):8696-8703. |
|
| 2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 . |
|
| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343809/2011-06-21 |
|
| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343808/2011-06-21 |
|
| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343810/2011-06-21 |
|
| 2011-06 |
Hot topic: Opportunities and potential challenges for the treatment of metabolic syndrome |
Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1420. |
|
| 2011-05-25 |
Pyrrolidine derivatives |
ZA201006329B/2011-05-25 |
|
| 2011-05-10 |
Imidazolidinone and imidazolidinethione derivatives |
US7939523B2/2011-05-10 |
|
| 2011-04 |
Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952. |
|
| 2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2011 Mar 27;241:258-MEDI. |
|
| 2011-03-21 |
吡唑化合物及其醫藥組成物 |
I339205/2011-03-21 |
|
| 2011-03-01 |
Thiourea derivatives |
US7897764B2/2011-03-01 |
|
| 2011-03 |
Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes |
Journal of Virology. 2011 Mar;85(6):2927-2941. |
|
| 2011-02 |
Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability |
Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117. |
|
| 2011-01-13 |
Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes |
Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178. |
|
| 2011-01 |
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay |
Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238. |
|
| 2011-01 |
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities |
Cancer Science. 2011 Jan;102(1):182-191. |
|
| 2010-12-01 |
吲哚化合物 |
ZL200480034988.8/2010-12-01 |
|
| 2010-12-01 |
抗肿瘤化合物 |
ZL200580045509.7/2010-12-01 |
|
| 2010-12 |
Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening |
Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774. |
|
| 2010-11-16 |
Thiophene compounds |
US7834046B2/2010-11-16 |
|
| 2010-11 |
Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus |
Antiviral Research. 2010 Nov;88(2):160-168. |
|
| 2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
Journal of Medicinal Chemistry. 2010 Oct 28;53(20):7316-7326. |
|
| 2010-10-06 |
吡咯烷化合物 |
ZL200580009891.6/2010-10-06 |
|
| 2010-10 |
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities |
Pharmacological Research. 2010 Oct;62(4):337-343. |
|
| 2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
ChemMedChem. 2010 Oct;5(10):1707-1716. |
|
| 2010-09-28 |
Selenophene compounds |
US7803799B2/2010-09-28 |
|
| 2010-09-01 |
Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry. 2010 Sep ;18(17):6414-6421. |
|
| 2010-09 |
Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist |
ChemMedChem. 2010 Sep;5(9):1439-1443. |
|
| 2010-08-21 |
硫尿化合物及抑制C型肝炎病毒感染之方法 |
I329102/2010-08-21 |
|
| 2010-08 |
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein |
Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583. |
|
| 2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models |
Abstracts of Papers - American Chemical Society. 2010 Aug;240:MEDI 332. |
|
| 2010-07 |
Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 |
Anticancer Research. 2010 Jul;30(7):2813-2822. |
|
| 2010-06-15 |
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600. |
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