| 2013-10 |
Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats |
Journal of Controlled Release. 2013 Oct;172(2):513-522. |
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| 2013-10 |
Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT |
Biomaterials. 2013 Oct;34(32):7994-8001. |
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| 2013-07 |
Andrographis paniculata extract and andrographolide modulate the hepatic drug metabolism system and plasma tolbutamide concentrations in rats |
Evidence-Based Complementary and Alternative Medicine. 2013 Jul;2013:Article number 982689. |
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| 2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260. |
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| 2013-06-05 |
Anticancer oral formulation |
EP2310363B1/2013-06-05 |
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| 2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867. |
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| 2013-06 |
Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence |
Journal of Microbiology. 2013 Jun;51(3):345-351. |
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| 2013-05 |
H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline in senescent human fetal mesenchymal stem cells |
Antioxidants and Redox Signaling. 2013 May;18(15):1895-1905. |
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| 2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
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| 2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 300-MEDI. |
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| 2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112 |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 299-MEDI. |
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| 2013-04 |
Design and synthesis of Aurora kinase inhibitors as anticancer agents |
Abstracts of Papers - American Chemical Society. 2013 Apr;245:Article number 301-MEDI. |
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| 2013-02-11 |
抗癌口服藥學組成物 |
I384984/2013-02-11 |
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| 2013-01-23 |
In vivo imaging of brain infarct with the novel fluorescent probe psvue 794 in a rat middle cerebral artery occlusion-reperfusion model |
Molecular Imaging. 2013 Jan 23;12(1):8-16. |
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| 2013-01 |
Effects of pH on molecular mechanisms of chitosan–integrin interactions and resulting tight-junction disruptions |
Biomaterials. 2013 Jan;34(3):784-793. |
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| 2012-11 |
BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia |
European Journal of Cancer. 2012 Nov;48(Suppl. 6):53-54. |
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| 2012-09 |
Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan |
Biomaterials. 2012 Sep;33(26):6254-6263. |
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| 2012-09 |
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors |
European Journal of Medicinal Chemistry. 2012 Sep;55:32-38. |
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| 2012-09 |
Putative tumor metastasis-associated genes in human gastric cancer |
International Journal of Oncology. 2012 Sep;41(3):1068-1084. |
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| 2012-09 |
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy |
Clinical Cancer Research. 2012 Sep;18(17):4691-4701. |
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| 2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659. |
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| 2012-06 |
Involvement of transcriptional regulator Ndt80 in stress responses of Candida albicans |
Mycoses. 2012 Jun;55(Suppl. S4):131-132. |
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| 2012-04 |
Securin enhances the anti-cancer effects of 6-Methoxy-3-(3′,4′,5′-Trimethoxy-Benzoyl)-1H-Indole (BPR0L075) in human colorectal cancer cells |
PLoS ONE. 2012 Apr;7(4):Article number e36006. |
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| 2012-03 |
R432 is a key residue for the multiple functions of Ndt80p in Candida albicans |
Cellular and Molecular Life Sciences. 2012 Mar;69(6):1011-1023. |
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| 2012-02 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents |
Investigational New Drugs. 2012 Feb;30(1):164-175. |
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| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
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| 2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
British Journal of Cancer. 2012 Jan;106(3):475-481. |
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| 2011-11 |
Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins |
Biomaterials. 2011 Nov;32(33):8712-8721. |
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| 2011-10 |
Antiproliferative effects of N-heterocyclic indolyl glyoxylamide derivatives on human lung cancer cells |
Anticancer Research. 2011 Oct;31(10):3407-3415. |
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| 2011-09-27 |
Formulations of indol-3-yl-2-oxoacetamide compounds |
US8026271B2/2011-09-27 |
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| 2011-09 |
Effects of dipeptidyl peptidase 4 inhibition with MK-0431 on syngeneic mouse islet transplantation |
Diabetologia. 2011 Sep;54(Suppl. 1):S181. |
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| 2011-07 |
Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model |
Laboratory Investigation. 2011 Jul;91(7):1029-1039. |
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| 2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 . |
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| 2011-05 |
Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4 |
Journal of Agricultural and Food Chemistry. 2011 May;59(9):4644-4648. |
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| 2011-05 |
Study of glioblastoma multiforme metastatic and invasive mechanism by polycistronic imaging probe in tumor implanted animal model |
Journal of Nuclear Medicine. 2011 May;52(Suppl. 1):Meeting Abstract 1709. |
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| 2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2011 Mar 27;241:258-MEDI. |
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| 2011-01-13 |
Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes |
Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178. |
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| 2011-01 |
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities |
Cancer Science. 2011 Jan;102(1):182-191. |
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| 2010-12 |
Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening |
Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774. |
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| 2010-11 |
Self-assembled pH-sensitive nanoparticles: A platform for oral delivery of protein drugs |
Advanced Functional Materials. 2010 Nov;20(21):3695-3700. |
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| 2010-11 |
Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae? |
PLoS ONE. 2010 Nov;5(11):Article number e15005. |
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| 2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
Journal of Medicinal Chemistry. 2010 Oct 28;53(20):7316-7326. |
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| 2010-09 |
Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type |
Cancer Chemotherapy and Pharmacology. 2010 Sep;66(4):773-783. |
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| 2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models |
Abstracts of Papers - American Chemical Society. 2010 Aug;240:MEDI 332. |
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| 2010-07 |
Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 |
Anticancer Research. 2010 Jul;30(7):2813-2822. |
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| 2010-06-15 |
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV |
Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600. |
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| 2010-05-11 |
咪唑胺化合物 |
I324596/2010-05-11 |
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| 2010-05-11 |
咪唑啉酮化合物 |
I324594/2010-05-11 |
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| 2010-04-21 |
吲哚-3-基-2-氧乙醯胺衍生物之新化合物及其醫藥組合物與製備方法 |
I323658/2010-04-21 |
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| 2010-03 |
Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice |
Obesity. 2010 Mar;18(3):463-469. |
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