國家衛生研究院 NHRI:
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    Patents [0/18]
    Periodical Articles [157/157]
    Conference Papers/Meeting Abstract [23/37]

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    Showing items 1-25 of 212. (9 Page(s) Totally)
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    DateTitleRelation
    2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
    2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia Cell Chemical Biology. 2024 Jul 17;Article in Press.
    2024-06-01 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
    2024-02-16 Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo ACS Food Science and Technology. 2024 Feb 16;4(2):479-490.
    2023-07-20 Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
    2023-02-07 Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
    2023-01-19 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] Pharmaceutics. 2023 Jan 19;15(2):Article number 342.
    2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
    2022-12-02 Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies Journal of Medical Virology. 2022 Dec 2;95:Article number e28370.
    2022-11-15 BPR0C261, an analogous of microtubule disrupting agent D-24851 enhances the radiosensitivity of human non-small cell lung cancer cells via p53-dependent and p53-independent pathways International Journal of Molecular Sciences. 2022 Nov 15;23(22):Article number 14083.
    2022-11-01 Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis Clinica Chimica Acta. 2022 Nov 1;536:45-55.
    2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
    2022-10-13 Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824.
    2022-10-03 Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730.
    2022-07-21 The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.
    2022-06-21 Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids Pharmaceutics. 2022 Jun 21;14(7):Article number 1316.
    2022-05-02 Furin and TMPRSS2 resistant spike induces robust humoral and cellular immunity against SARS-CoV-2 lethal infection Frontiers in Immunology. 2022 May 2;13:Article number 872047.
    2022-03-02 Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782.
    2022-02-15 Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587.
    2021-12 Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice Biomedical Journal. 2021 Dec;44(6 Suppl 2):S210-S217.
    2021-11-15 Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673.
    2021-10-14 Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
    2021-10-01 Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport Advanced Materials. 2021 Oct 01;201:Article number 2104139.
    2021-08-13 Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 Frontiers in Pharmacology. 2021 Aug 13;12:Article number 706901.
    2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Life Sciences. 2021 Aug 1;278:Article number 119574.

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