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显示项目101-125 / 142. (共6页) << < 1 2 3 4 5 6 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2008-05	Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana	Phytotherapy Research. 2008 May;22(5):605-613.
2008-04-15	Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus	Biochemical Pharmacology. 2008 Apr;75(8):1601-1609.
2008-03-13	Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors	Journal of Medicinal Chemistry. 2008 Mar;51(5):1464-1468.
2008-03-10	Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent	Tetrahedron. 2008 Mar;64(11):2586-2595.
2008-03-01	Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold	Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627.
2008-02-07	First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol	Organic Letters. 2008 Feb 7;10(3):449-452.
2008-02	A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells	Anti-Cancer Drugs. 2008 Feb;19(2):151-158.
2007-12	Strategies of development of antiviral agents directed against influenza virus replication	Current Pharmaceutical Design. 2007 Dec;13(34):3531-3542.
2007-09-06	4-and 5-aroylindoles as novel classes of potent antitubulin agents	Journal of Medicinal Chemistry. 2007 Sep;50(18):4548-4552.
2007-07-31	Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil	British Journal of Cancer. 2007 Jul;97(3):334-344.
2007-07	Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes	Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049.
2007-03-01	3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes	Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279.
2007-02-08	Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells	Cancer Letters. 2007 Feb;246(1-2):237-252.
2007-02-01	Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study	Journal of Chromatography B. 2007 Feb;846(1-2):162-168.
2006-12	Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats	Journal of Food and Drug Analysis. 2006 Dec;14(4):329-333.
2006-11-16	7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents	Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659.
2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
2006-10	Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents	ChemMedChem. 2006 Oct;1(10):1106-1118.
2006-08-24	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease	Journal of Medicinal Chemistry. 2006 Aug;49(17):5154-5161.
2006-07	Antiviral drug discovery against SARS-CoV	Current Medicinal Chemistry. 2006 Jul;13(17):2003-2020.
2006-06-15	Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors	Bioorganic and Medicinal Chemistry Letters. 2006 Jun;16(12):3268-3272.
2006-06-15	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies	Journal of Medicinal Chemistry. 2006 Jun;49(12):3485-3495.
2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	Journal of Medicinal Chemistry. 2006 May;49(9):2703-2712.
2006-05	Antitubulin agents for the treatment of cancer - a medicinal chemistry update	Expert Opinion on Therapeutic Patents. 2006 May;16(5):647-691.
2006-02-09	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies	Journal of Medicinal Chemistry. 2006 Feb;49(3):1212-1216.

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