國家衛生研究院 NHRI:Items for Author

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Items for Author "Hsieh HP"

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Collection	Date	Title	Relation
[伍素瑩] 期刊論文	2009-07-23	Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity	-
[伍素瑩] 期刊論文	2006-08-24	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease	-
[伍素瑩] 期刊論文	2006-06-15	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies	-
[伍素瑩] 期刊論文	2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	-
[其他] 期刊論文	2009-04-24	Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway	-
[喻秋華] 期刊論文	2019-10-08	Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity	-
[夏克山] 期刊論文	2015-02	Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors	-
[張俊彥] 期刊論文	2024-05-09	Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function	-
[張俊彥] 期刊論文	2019-12	Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry	-
[張俊彥] 期刊論文	2011-09	Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents	-
[張俊彥] 期刊論文	2011-08	BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells	-
[張俊彥] 期刊論文	2010-09	Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes	-
[張俊彥] 期刊論文	2010-03-11	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	-
[張俊彥] 期刊論文	2009-07-03	Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers	-
[張俊彥] 期刊論文	2009-04-17	Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents	-
[張俊彥] 期刊論文	2009-04	Aurora kinase inhibitors in preclinical and clinical testing	-
[張俊彥] 期刊論文	2008-07-24	Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors	-
[張俊彥] 期刊論文	2008-02	A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells	-
[張俊彥] 期刊論文	2007-09-06	4-and 5-aroylindoles as novel classes of potent antitubulin agents	-
[張俊彥] 期刊論文	2007-07-31	Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil	-
[張俊彥] 期刊論文	2006-11-16	7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents	-
[張俊彥] 期刊論文	2004-07-15	A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells	-
[張俊彥] 期刊論文	2004-07-01	BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo	-
[張俊彥] 期刊論文	2003-03-10	Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents (vol 13, pg 101, 2003)	-
[張俊彥] 期刊論文	2003-01-06	Structure-activity and crystallographic analysis of benzophenone derivatives - the potential anticancer agents	-
[張文祥] 期刊論文	2010-06	Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis	-
[徐祖安] 專利	2011-06-21	抑制冠狀病毒之醫藥組合物	-
[徐祖安] 專利	2011-06-21	抑制冠狀病毒之醫藥組合物	-
[徐祖安] 專利	2011-06-21	抑制冠狀病毒之醫藥組合物	-
[徐祖安] 專利	2009-06-09	Treatment of coronavirus infection	-
[徐祖安] 專利	2008-02-11	一種抗病毒之醫藥組合物	-
[徐祖安] 會議論文/會議摘要	2014-03	DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study	-
[徐祖安] 會議論文/會議摘要	2011-03	Potent EGFR tyrosine kinase inhibitors as anticancer agents	-
[徐祖安] 期刊論文	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	-
[徐祖安] 期刊論文	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	-
[徐祖安] 期刊論文	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	-
[徐祖安] 期刊論文	2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	-
[徐祖安] 期刊論文	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	-
[徐祖安] 期刊論文	2013-02-20	Parallel screening of Wild-Type and drug-resistant targets for anti-resistance neuraminidase inhibitors	-
[徐祖安] 期刊論文	2012-02	Identification of BPR3P0128 as an Inhibitor of cap-snatching activities of influenza virus	-
[徐祖安] 期刊論文	2012-01	A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors	-
[徐祖安] 期刊論文	2010-01	BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses	-
[徐祖安] 期刊論文	2009-02	Aurintricarboxylic acid inhibits influenza virus neuraminidase	-
[徐祖安] 期刊論文	2008-05	Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana	-
[徐祖安] 期刊論文	2005	Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3 '- digallate (TF3)	-
[徐祖安] 期刊論文	2004-09-10	Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV	-
[徐祖安] 期刊論文	2004-07	Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide	-
[李秀珠] 會議論文/會議摘要	2004-09	Drug design of BPR0L075 as an anticancer agent	-
[李秀珠] 會議論文/會議摘要	2004-07	Drug design for BPR0L075 as an anticancer agent	-
[李秀珠] 會議論文/會議摘要	2003	The synthetic 1-aroylindoles and 3-aroylindoles derivatives, combretastatin A-4 analogues, as a novel class of potent anticancer agents	-
[林峯輝] 期刊論文	2024-06-24	Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease	-
[紀雅惠] 期刊論文	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	-
[葉修華] 期刊論文	2024-10-29	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	-
[葉修華] 期刊論文	2023-10-05	A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects	-
[葉燈光] 會議論文/會議摘要	2019-10	Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer	-
[葉燈光] 會議論文/會議摘要	2017-04	Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[葉燈光] 會議論文/會議摘要	2013-11	A development drug candidate targeting EGFR kinase for lung cancer: DBPR112	-
[葉燈光] 期刊論文	2007-07	Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes	-
[蔣維棠] 專利	2012-04-21	吡咯啉啶化合物	-
[蔣維棠] 專利	2012-01-17	Pyrrolidine compounds	-
[蔣維棠] 專利	2010-10-06	吡咯烷化合物	-
[蔣維棠] 專利	2010-03-30	Pyrrolidine compounds	-
[蔣維棠] 專利	2008-09-16	Pyrrolidine compounds	-
[蔣維棠] 專利	2008-07-21	吡咯啉啶化合物	-
[蔣維棠] 專利	2008-07-01	Pyrrolidine compounds	-
[蔣維棠] 期刊論文	2007-03-01	3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes	-
[蔣維棠] 期刊論文	2006-06-15	Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors	-
[蔣維棠] 期刊論文	2006-01-12	2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	-
[謝興邦] 專利	2015-07-31	作為極光激酶抑制劑的稠合雙環嘧啶化合物	-
[謝興邦] 專利	2015-07-22	作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物	-
[謝興邦] 專利	2015-04-14	Fused multicyclic compounds as protein kinase inhibitors	-
[謝興邦] 專利	2014-10-29	作為極光激酶抑制劑的稠合雙環嘧啶化合物	-
[謝興邦] 專利	2014-10-21	化合物於製造治療病毒感染的藥物之用途	-
[謝興邦] 專利	2014-04-29	Quinoline compounds and their use for treating viral infection	-
[謝興邦] 專利	2014-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	-
[謝興邦] 專利	2013-11-21	治療癌症的醫藥組成物	-
[謝興邦] 專利	2013-10-01	喹啉化合物及包含其之治療病毒感染之醫藥組成物	-
[謝興邦] 專利	2013-08-21	Fused multicyclic compounds as protein kinase inhibitors	-
[謝興邦] 專利	2013-08-13	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors	-
[謝興邦] 專利	2013-07-01	做為蛋白質激酶抑制劑之稠合多環化合物	-
[謝興邦] 專利	2013-02-11	作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物	-
[謝興邦] 專利	2012-05-11	作為極光激酶抑制劑之稠合雙環嘧啶化合物	-
[謝興邦] 專利	2012-03-20	Fused bicyclic pyrimidine compounds as aurora kinase inhibitors	-
[謝興邦] 專利	2012-03-06	Indole compounds	-
[謝興邦] 專利	2011-11-15	Coumarin compounds and their use for treating cancer	-
[謝興邦] 專利	2011-07-11	抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物	-
[謝興邦] 專利	2011-04-06	Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis related disorders	-
[謝興邦] 專利	2010-12-01	吲哚化合物	-
[謝興邦] 專利	2010-12-01	抗肿瘤化合物	-
[謝興邦] 專利	2009-12-15	Indole compounds	-
[謝興邦] 專利	2009-12-01	芳香羰吲哚化合物	-
[謝興邦] 專利	2009-05-05	Indole compounds	-
[謝興邦] 專利	2008-12-11	吲哚化合物	-
[謝興邦] 專利	2008-11-25	Anti-tumor compounds	-
[謝興邦] 專利	2008-11-11	Indole compounds	-
[謝興邦] 專利	2008-05-01	抗腫瘤化合物	-
[謝興邦] 專利	2005-08-23	Indole compounds	-
[謝興邦] 會議論文/會議摘要	2023-10	Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs	-
[謝興邦] 會議論文/會議摘要	2019-10	The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy	-
[謝興邦] 會議論文/會議摘要	2018-07	Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer	-
[謝興邦] 會議論文/會議摘要	2017-04	Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone	-
[謝興邦] 會議論文/會議摘要	2017-04	One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation	-
[謝興邦] 會議論文/會議摘要	2015-08	BPR2P001S0, a Coumarin derivative, induced cell cycle arrest in A549 through inhibiting PDPK1 activity	-
[謝興邦] 會議論文/會議摘要	2015-08	Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma	-
[謝興邦] 會議論文/會議摘要	2015-08	Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2014-11	Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent	-
[謝興邦] 會議論文/會議摘要	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	-
[謝興邦] 會議論文/會議摘要	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	-
[謝興邦] 會議論文/會議摘要	2014-03	Efficient virtual screening using ligand efficiency based approach	-
[謝興邦] 會議論文/會議摘要	2013-11	Peptide-mediated liposomal doxorubicin enhances drug delivery efficiency and therapeutic efficacy in lung cancer animal models	-
[謝興邦] 會議論文/會議摘要	2013-04-07	BPR000K, a novel Aurora kinase inhibitor	-
[謝興邦] 會議論文/會議摘要	2013-04-07	Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis	-
[謝興邦] 會議論文/會議摘要	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	-
[謝興邦] 會議論文/會議摘要	2013-04-07	Development drug candidate targeting EGFR kinase: DBPR112	-
[謝興邦] 會議論文/會議摘要	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	-
[謝興邦] 會議論文/會議摘要	2012-03-25	Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2011-09-23	BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo	-
[謝興邦] 會議論文/會議摘要	2011-04	Antivascular activities of novel tubulin binding agent BPR0L075	-
[謝興邦] 會議論文/會議摘要	2011-03-27	Design and synthesis of potent Aurora kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2011-03	SAR studies of quinoline derivatives as novel anti-influenza agents	-
[謝興邦] 會議論文/會議摘要	2010-08	Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models	-
[謝興邦] 會議論文/會議摘要	2009-09	Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development	-
[謝興邦] 會議論文/會議摘要	2009-05	Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms	-
[謝興邦] 會議論文/會議摘要	2009-03	Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2007-07	Anti-influenza drug discovery	-
[謝興邦] 會議論文/會議摘要	2007-07	From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents	-
[謝興邦] 會議論文/會議摘要	2006-09	MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes	-
[謝興邦] 會議論文/會議摘要	2005-03	Promazine analogues as potential anti SARS-CoV drugs	-
[謝興邦] 會議論文/會議摘要	2005-03	Design, synthesis and sar of indole-based PPAR agonists	-
[謝興邦] 會議論文/會議摘要	2005-03	Design and structure-activity relationships of novel indole-based PPAR agonists as antidiabetic agents	-
[謝興邦] 會議論文/會議摘要	2004-08-22	Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents	-
[謝興邦] 會議論文/會議摘要	2002-08	Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents	-
[謝興邦] 期刊論文	2024-06-24	Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment	-
[謝興邦] 期刊論文	2023-11-03	Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone	-
[謝興邦] 期刊論文	2023-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	-
[謝興邦] 期刊論文	2022-09-12	A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies	-
[謝興邦] 期刊論文	2022-08-09	Recent advances in total synthesis of natural products by masked ortho-benzoquinones	-
[謝興邦] 期刊論文	2022-05-09	Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer	-
[謝興邦] 期刊論文	2022-04-06	Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2	-
[謝興邦] 期刊論文	2021-11-15	Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization	-
[謝興邦] 期刊論文	2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	-
[謝興邦] 期刊論文	2021-04-16	Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors	-
[謝興邦] 期刊論文	2021-02-22	Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design	-
[謝興邦] 期刊論文	2021-01-31	Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908)	-
[謝興邦] 期刊論文	2021-01-15	One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C	-
[謝興邦] 期刊論文	2021-01	Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors	-
[謝興邦] 期刊論文	2020-12-10	Tumor-agnostic inhibitors in oncology: A new phase for precision medicine	-
[謝興邦] 期刊論文	2020-08	Design of a potent anticancer lead inspired by natural products from traditional Indian medicine	-
[謝興邦] 期刊論文	2020-07	Design of drug-like hepsin inhibitors against prostate cancer and kidney stones	-
[謝興邦] 期刊論文	2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	-
[謝興邦] 期刊論文	2020-03-01	A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis	-
[謝興邦] 期刊論文	2020-01	Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening	-
[謝興邦] 期刊論文	2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	-
[謝興邦] 期刊論文	2019-07-03	Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study	-
[謝興邦] 期刊論文	2019-07	Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation	-
[謝興邦] 期刊論文	2019-05-29	Insights for the design of protein lysine methyltransferase G9a inhibitors	-
[謝興邦] 期刊論文	2018-11	Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D	-
[謝興邦] 期刊論文	2017-08-11	Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer	-
[謝興邦] 期刊論文	2017-07	Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[謝興邦] 期刊論文	2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	-
[謝興邦] 期刊論文	2016-07	Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792	-
[謝興邦] 期刊論文	2016-03	Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target survivin	-
[謝興邦] 期刊論文	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	-
[謝興邦] 期刊論文	2014-12	BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71	-
[謝興邦] 期刊論文	2014-10	Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer	-
[謝興邦] 期刊論文	2014-08	CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors	-
[謝興邦] 期刊論文	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	-
[謝興邦] 期刊論文	2014-07	Anaplastic lymphoma kinase (ALK) inhibitors: A review of design and discovery	-
[謝興邦] 期刊論文	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	-
[謝興邦] 期刊論文	2013-07-25	Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway	-
[謝興邦] 期刊論文	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	-
[謝興邦] 期刊論文	2013-06	An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells	-
[謝興邦] 期刊論文	2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	-
[謝興邦] 期刊論文	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	-
[謝興邦] 期刊論文	2013-01	Substituent effects on the photorearrangements of unsymmetrically substituted diazinobarrelenes	-
[謝興邦] 期刊論文	2012-12	An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold	-
[謝興邦] 期刊論文	2012-09	Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization	-
[謝興邦] 期刊論文	2012-08-24	Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts	-
[謝興邦] 期刊論文	2011-09	Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway	-
[謝興邦] 期刊論文	2011-06	Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10)	-
[謝興邦] 期刊論文	2011-04-28	Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents	-
[謝興邦] 期刊論文	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	-
[謝興邦] 期刊論文	2010-02-25	Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives	-
[謝興邦] 期刊論文	2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	-
[謝興邦] 期刊論文	2010-02	Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site	-
[謝興邦] 期刊論文	2009-08-13	Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach	-
[謝興邦] 期刊論文	2009-04-23	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists	-
[謝興邦] 期刊論文	2009-03	Advances in Aurora kinase inhibitor patents	-
[謝興邦] 期刊論文	2009-02-26	Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity	-
[謝興邦] 期刊論文	2008-12-25	Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents	-
[謝興邦] 期刊論文	2008-07	Anti-HSV activity of digitoxin and its possible mechanisms	-
[謝興邦] 期刊論文	2008-03-13	Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors	-
[謝興邦] 期刊論文	2008-03-10	Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent	-
[謝興邦] 期刊論文	2008-03-01	Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold	-
[謝興邦] 期刊論文	2008-02-07	First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol	-
[謝興邦] 期刊論文	2007-12	Strategies of development of antiviral agents directed against influenza virus replication	-
[謝興邦] 期刊論文	2007-02-01	Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study	-
[謝興邦] 期刊論文	2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	-
[謝興邦] 期刊論文	2006-10	Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents	-
[謝興邦] 期刊論文	2006-07	Antiviral drug discovery against SARS-CoV	-
[謝興邦] 期刊論文	2006-05	Antitubulin agents for the treatment of cancer - a medicinal chemistry update	-
[謝興邦] 期刊論文	2006-02-09	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies	-
[謝興邦] 期刊論文	2006-01-01	Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system	-
[謝興邦] 期刊論文	2005-12-29	Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities	-
[謝興邦] 期刊論文	2005-05	Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells - Role of NF-kappa B	-
[謝興邦] 期刊論文	2005-05	Pharmaceutical design of antimitotic agents based on combretastatins	-
[謝興邦] 期刊論文	2004-08-12	Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents	-
[謝興邦] 期刊論文	2004-05-20	Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents	-
[謝興邦] 期刊論文	2003-12-01	Substituent effects on di-pi-methane and aza-di-pi-methane rearrangements of dibenzo[f,h]quinoxalinobarrelenes	-
[謝興邦] 期刊論文	2002-06-06	Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents	-
[賴基銘(2004-2008)] 期刊論文	2007-02-08	Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells	-
[趙宇生(2002-2013)] 專利	2009-01-22	Pyrrolidine compounds	-
[趙宇生(2002-2013)] 期刊論文	2010-10-28	Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency	-
[趙宇生(2002-2013)] 期刊論文	2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	-
[趙宇生(2002-2013)] 期刊論文	2010-07	Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075	-
[趙宇生(2002-2013)] 期刊論文	2010-02-23	Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity	-
[郭靜娟] 會議論文/會議摘要	2018-07	Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer	-
[鄒倫] 期刊論文	2021-04-13	Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)	-
[陳怡榮] 期刊論文	2008-06-01	A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors	-
[陳新(2002-2015)] 期刊論文	2008-04-15	Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus	-
[陳炯東] 會議論文/會議摘要	2018-01	Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer	-
[陳炯東] 會議論文/會議摘要	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	-
[陳炯東] 期刊論文	2006-12	Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats	-
[陳立宗] 期刊論文	2011-03-07	2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors	-
[陳立宗] 期刊論文	2003-06-15	Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent	-
[顏婉菁] 期刊論文	2022-01-21	Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma	-
[黃明熙] 期刊論文	2021-07-16	Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens	-

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Items for Author "Hsieh HP"