| 2013-11-21 |
治療癌症的醫藥組成物 |
I415852/2013-11-21 |
|
| 2013-11-13 |
Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice |
Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933. |
 |
| 2013-11 |
Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors |
Bioorganic and Medicinal Chemistry. 2013 Nov;21(21):6282-6291. |
|
| 2013-11 |
BPR0C305, an orally active microtubule-disrupting anticancer agent |
Anticancer Drugs. 2013 Nov;24(10):1047-1057. |
|
| 2013-11 |
A development drug candidate targeting EGFR kinase for lung cancer: DBPR112 |
Journal of Thoracic Oncology. 2013 Nov;8(Suppl. 2):S779-S780. |
|
| 2013-11 |
Peptide-mediated liposomal doxorubicin enhances drug delivery efficiency and therapeutic efficacy in lung cancer animal models |
Journal of Thoracic Oncology. 2013 Nov;8(Suppl. 2):S779. |
|
| 2013-10-01 |
喹啉化合物及包含其之治療病毒感染之醫藥組成物 |
I410245/2013-10-01 |
|
| 2013-10 |
Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats |
Journal of Controlled Release. 2013 Oct;172(2):513-522. |
|
| 2013-10 |
Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT |
Biomaterials. 2013 Oct;34(32):7994-8001. |
|
| 2013-10 |
Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure |
International Journal of Cardiology. 2013 Oct;168(4):4178-4183. |
|
| 2013-10 |
Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification |
Biochemical Pharmacology. 2013 Oct;86(7):872-887. |
|
| 2013-09-27 |
Pyrrolidine derivatives |
RU2494094C2/2013-09-27 |
|
| 2013-09-24 |
Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats |
Human and Experimental Toxicology. 2013 Sep 24;33(6):638-649. |
|
| 2013-09-22 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411] |
International Journal of Biological Sciences. 2013 Sep 22;9(9):947. |
|
| 2013-09-11 |
噻吩化合物及其醫藥組成物 |
I408136/2013-09-11 |
|
| 2013-09 |
Furanylazaindoles: Potent anticancer agents in vitro and in vivo |
Journal of Medicinal Chemistry. 2013 Sep;56(20):8008-8018. |
|
| 2013-08-21 |
Fused multicyclic compounds as protein kinase inhibitors |
EP2331530B1/2013-08-21 |
|
| 2013-08-13 |
Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
US8507502B2/2013-08-13 |
|
| 2013-08 |
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-alpha–induced TGF-alpha expression and MEK/VEGF-A–mediated angiogenesis |
American Journal of Pathology. 2013 Aug;183(2):566-575. |
|
| 2013-08 |
Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum |
Journal of Biological Chemistry. 2013 Aug;288(35):25330-25339. |
|
| 2013-07-25 |
Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway |
International Journal of Nanomedicine. 2013 Jul 25;2013(8):2689-2707. |
|
| 2013-07-16 |
Dibenzo[f,h]isoquinoline derivatives |
US8486959B2/2013-07-16 |
|
| 2013-07-08 |
1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors |
ChemBioChem. 2013 Jul 8;14(10):1248-1254. |
|
| 2013-07-08 |
Inside Cover: 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors(ChemBioChem 10/2013) |
ChemBioChem. 2013 Jul 8;14(10):1150. |
|
| 2013-07-01 |
做為蛋白質激酶抑制劑之稠合多環化合物 |
I400242/2013-07-01 |
|
| 2013-07 |
CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions |
Pharmacogenomics. 2013 Jul;14(10):1191-1201. |
|
| 2013-07 |
Andrographis paniculata extract and andrographolide modulate the hepatic drug metabolism system and plasma tolbutamide concentrations in rats |
Evidence-Based Complementary and Alternative Medicine. 2013 Jul;2013:Article number 982689. |
|
| 2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260. |
|
| 2013-06-05 |
Anticancer oral formulation |
EP2310363B1/2013-06-05 |
|
| 2013-06 |
c-Jun-mediated anti-cancer mechanisms of tylophorine |
Carcinogenesis. 2013 Jun;34(6):1304-1314. |
|
| 2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867. |
|
| 2013-06 |
Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities |
Organic and Biomolecular Chemistry. 2013 Jun;11(24):3943-3948. |
|
| 2013-06 |
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells |
PLoS ONE. 2013 Jun;8(6):Article number e65686. |
|
| 2013-06 |
Heart failure and angiotensin II modulate atrial Pitx2c promotor methylation |
Clinical and Experimental Pharmacology and Physiology. 2013 Jun;40(6):379-384. |
|
| 2013-06 |
Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence |
Journal of Microbiology. 2013 Jun;51(3):345-351. |
|
| 2013-05-14 |
Phenanthroindolizidine analogues |
US8440649B2/2013-05-14 |
|
| 2013-05 |
H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline in senescent human fetal mesenchymal stem cells |
Antioxidants and Redox Signaling. 2013 May;18(15):1895-1905. |
|
| 2013-05 |
Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus |
Antiviral Research. 2013 May;98(2):228-241. |
|
| 2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
|
| 2013-05 |
Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines |
Journal of Immunology. 2013 May;190(10):5065-5077. |
|
| 2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors |
Journal of Medicinal Chemistry. 2013 May;56(10):3889-3903. |
|
| 2013-04-30 |
Pyrrolidine derivatives |
164613/2013-04-30 |
|
| 2013-04-29 |
A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment |
International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411. |
|
| 2013-04-13 |
Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents |
FASEB Journal. 2013 Apr 13;27:lb71. |
|
| 2013-04-09 |
Proline derivatives |
US8415482B2/2013-04-09 |
|
| 2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 300-MEDI. |
|
| 2013-04-07 |
Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 298-MEDI |
|
| 2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 87-MEDI. |
|
| 2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112 |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 299-MEDI. |
|
| 2013-04 |
Palladium(0)/copper(I)-catalyzed tandem cyclization of aryl 1-cyanoalk-5-ynyl ketone system: Rapid assembly of cyclopenta[b]naphthalene and benzo[b]fluorene derivatives |
Advanced Synthesis and Catalysis. 2013 Apr;355(7):1323-1337. |
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