國家衛生研究院 NHRI:
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    日期題名關聯
    2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
    2019-04-01 A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
    2019-04-01 The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
    2019-03-28 Phase-changeable nanoemulsions for oral delivery of a therapeutic peptide: Toward targeting the pancreas for antidiabetic treatments using lymphatic transport Advanced Functional Materials. 2019 Mar 28;29(13): Article number 1809015.
    2019-03 Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors Bioorganic Chemistry. 2019 Mar;83:520-525.
    2019-03 Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A Journal of General Virology. 2019 Mar;100(3):457-470.
    2019-01 CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma Journal of Cellular Physiology. 2019 Jan;234(6):9118-9129.
    2019-01 CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-Beta Wnt and STAT3 signaling pathways Journal of Food and Drug Analysis. 2019 Jan;27(1):184-194.
    2018-12 Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer Cancer Science. 2018 Dec;109(SI, Suppl. 2):210.
    2018-12 Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer Cancer Science. 2018 Dec;109(Suppl. 2, SI):1257.
    2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor Cancer Science. 2018 Nov;109(11):3591-3601.
    2018-07 An intestinal "Transformers"-like nanocarrier system for enhancing the oral bioavailability of poorly water-soluble drugs ACS Nano. 2018 Jul;12(7):6389-6397.
    2018-07 4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664.
    2018-04 Effects of female sex hormones on folic acid-induced anti-angiogenesis Acta Physiologica. 2018 Apr;222:Article number e13001.
    2018-04 PSPC1 mediates TGF-beta1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis Nature Cell Biology. 2018 Apr;20(4):479-491.
    2018-02-08 Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond Journal of Medicinal Chemistry. 2018 Feb 8;61(3):818-833.
    2018-01-01 Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620.
    2018-01 Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer Cancer Science. 2018 Jan;109(Suppl. 1):739.
    2017-12 Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells Free Radical Biology and Medicine. 2017 Dec;113:505-518.
    2017-07-07 CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-kappaB pathways Scientific Reports. 2017 Jul 07;7(1):Article number 4862.
    2017-07 Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612.
    2017-07 Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates Bioconjugate Chemistry. 2017 Jul;28(7):1878-1892.
    2017-05 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine Anesthesiology. 2017 May;126(5):952-966.
    2017-04 A novel CXCR4 antagonist CX549 induces neuroprotection in stroke brain Cell Transplantation. 2017 Apr;26(4):571-583.
    2017-04 Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation Abstracts of Papers of the American Chemical Society. 2017 Apr;253:Meeting Abstract 482.

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