| 2024-12 |
Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma |
International Journal of Biological Macromolecules. 2024 Dec;283(Part 1):Article number 137296. |
 |
| 2024-11 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790. |
|
| 2024-06-24 |
Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease |
European Polymer Journal. 2024 Jun 24;214:Article number 113151. |
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| 2024-06-24 |
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment |
Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press. |
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| 2024-05-09 |
Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function |
Journal of Biomedical Science. 2024 May 09;31:Article number 46. |
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| 2023-11-03 |
Influence of ring strain on the formation of rearrangement vs cyclization isotwistane products in the acyl radical reaction of bicyclo[2.2.2]octanone |
Organic Letters. 2023 Nov 3;25(43):7757-7762. |
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| 2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects |
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608. |
|
| 2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs |
Annals of Oncology. 2023 Oct;34(Suppl. 2):S214. |
|
| 2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588. |
|
| 2022-09-12 |
A critical overview of current progress for COVID-19: Development of vaccines, antiviral drugs, and therapeutic antibodies |
Journal of Biomedical Science. 2022 Sep 12;29:Article number 68. |
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| 2022-08-09 |
Recent advances in total synthesis of natural products by masked ortho-benzoquinones |
Journal of the Chinese Chemical Society. 2022 Aug 09;69(8):1210-1222. |
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| 2022-05-09 |
Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer |
Journal of Biomedical Science. 2022 May 9;29:Article number 29. |
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| 2022-04-06 |
Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2 |
International Journal of Molecular Sciences. 2022 Apr 6;23(7):Article number 4050. |
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| 2022-01-21 |
Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma |
Journal of Biomedical Science. 2022 Jan 21;29:Article number 5. |
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| 2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673. |
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| 2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497. |
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| 2021-07-16 |
Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens |
Nanomaterials. 2021 Jul 16;11(7):Article number 1844. |
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| 2021-04-16 |
Development of a robust scale-up synthetic route for BPR1K871: A clinical candidate for the treatment of acute myeloid leukemia and solid tumors |
Organic Process Research and Development. 2021 Apr 16;25(4):817-830. |
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| 2021-04-13 |
Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908) |
Tetrahedron Letters. 2021 Apr 13;69:Article number 152976. |
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| 2021-02-22 |
Mimicking H3 substrate arginine in the design of G9a lysine methyltransferase inhibitors for cancer therapy: A computational study for structure-based drug design |
ACS Omega. 2021 Feb 22;6(9):6100-6111. |
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| 2021-01-31 |
Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908) |
Marine Drugs. 2021 Jan 31;19(2):Article number 77. |
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| 2021-01-15 |
One-pot synthesis of dibenzo[b,f]oxepines and total synthesis of bauhinoxepin C |
Journal of Organic Chemistry. 2021 Jan 15;86(2):1955-1963. |
|
| 2021-01 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors |
Chemical Biology and Drug Design. 2021 Jan;97(1):51-66. |
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| 2020-12-10 |
Tumor-agnostic inhibitors in oncology: A new phase for precision medicine |
Journal of the Chinese Chemical Society. 2020 Dec 10;67(12):2216-2224. |
|
| 2020-08 |
Design of a potent anticancer lead inspired by natural products from traditional Indian medicine |
Journal of Biomolecular Structure and Dynamics. 2020 Aug;38(12):3563-3577. |
|
| 2020-07 |
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones |
Acta Pharmaceutica Sinica B. 2020 Jul;10(7):1309-1320. |
|
| 2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
Bioorganic Chemistry. 2020 May;98:Article number 103689. |
|
| 2020-03-01 |
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis |
Cancer Letters. 2020 Mar 1;472:97-107. |
|
| 2020-01 |
Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening |
Biochimie. 2020 Jan;168:220-230. |
|
| 2019-12 |
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry |
Biochimica et Biophysica Acta. Molecular Cell Research. 2019 Dec;1866(12):Article number 118517. |
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| 2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
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| 2019-10-08 |
Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity |
Advanced Therapeutics. 2019 Oct 8;2(12):Article number 1900105. |
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| 2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
Annals of Oncology. 2019 Oct;30(Suppl. 5):789. |
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| 2019-10 |
The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy |
Annals of Oncology. 2019 Oct;30(Suppl. 5):786. |
|
| 2019-07-03 |
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: A molecular dynamics study |
Journal of Biomolecular Structure and Dynamics. 2019 Jul 3;37(10):2581-2592. |
|
| 2019-07 |
Dual Kit/Aur inhibitors as chemosensitizing agents for the treatment of melanoma: Design, synthesis, docking studies and functional investigation |
Scientific Reports. 2019 Jul;9:Article number 9943. |
|
| 2019-05-29 |
Insights for the design of protein lysine methyltransferase G9a inhibitors |
Future Medicinal Chemistry. 2019 May 29;11(9):993-1014. |
|
| 2018-11 |
Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D |
Angewandte Chemie. 2018 Nov;57(47):15572-15576. |
|
| 2018-07 |
Clinical candidate DBPR112: A novel epidermal growth factor receptor inhibitor as a promising treatment for non-small cell lung cancer |
Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 4789. |
|
| 2018-07 |
Blockage of EGFR signaling repurposes tumor metabolism through suppression of glycolysis and Kreb cycle in head and neck cancer |
Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 3944. |
|
| 2018-05-10 |
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition |
European Journal of Medicinal Chemistry. 2018 May 10;151:533-545. |
|
| 2018-04-25 |
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors |
European Journal of Medicinal Chemistry. 2018 Apr 25;150:491-505. |
|
| 2018-01 |
Discovery and development of DBPR112 as a clinical candidate: A novel EGFR inhibitor for non-small cell lung cancer |
Cancer Science. 2018 Jan;109(Suppl. 1):739. |
|
| 2017-08-11 |
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer |
Scientific Reports. 2017 Aug 11;7:Article number 7972. |
|
| 2017-07 |
Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors |
Journal of Biomolecular Structure and Dynamics. 2017 Jun;35(8):1833-1848. |
|
| 2017-04 |
Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
Abstracts of Papers of the American Chemical Society. 2017 Apr;253:Meeting Abstract 482. |
|
| 2017-04 |
Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone |
Abstracts of Papers of the American Chemical Society. 2017 Apr;253:Meeting Abstract 516. |
|
| 2017-04 |
One-pot tandem oxidative dearomatization/ 4+3 cycloaddition: Masked o-benzoquinone with diaza-oxyallyl cation |
Abstracts of Papers of the American Chemical Society. 2017 Apr;253:Meeting Abstract 185. |
|
| 2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
Oncotarget. 2016 Dec;7(52):86239-86256. |
|
| 2016-11-29 |
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design |
European Journal of Medicinal Chemistry. 2016 Nov 29;124:186-199. |
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ORCID:0000-0002-1332-005X6
