| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
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| 2009-07-03 |
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers |
Molecular Cancer. 2009 Jul 3;8:Article number 43. |
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| 2009-06-09 |
Treatment of coronavirus infection |
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| 2009-05-05 |
Indole compounds |
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| 2009-05 |
Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms |
Cancer Research. 2009 May;69:Abstract number 5542. |
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| 2009-04-24 |
Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway |
Journal of Biological Chemistry. 2009 Apr 24;284(17):11121-11133. |
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| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
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| 2009-04-17 |
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents |
ChemMedChem. 2009 Apr 17;4(4):588-593. |
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| 2009-04 |
Aurora kinase inhibitors in preclinical and clinical testing |
Expert Opinion on Investigational Drugs. 2009 Apr;18(4):379-398. |
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Advances in Aurora kinase inhibitor patents |
Expert Opinion on Therapeutic Patents. 2009 Mar;19(3):321-356. |
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| 2009-03 |
Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2009 Mar;237:MEDI 221. |
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| 2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062. |
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| 2009-02 |
Aurintricarboxylic acid inhibits influenza virus neuraminidase |
Antiviral Research. 2009 Feb;81(2):123-131. |
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| 2009-01-22 |
Pyrrolidine compounds |
AU2005221678/2009-01-22 |
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| 2008-12-25 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents |
Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167. |
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| 2008-12-11 |
吲哚化合物 |
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| 2008-11-25 |
Anti-tumor compounds |
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| 2008-11-11 |
Indole compounds |
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| 2008-09-16 |
Pyrrolidine compounds |
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| 2008-07-24 |
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors |
Journal of Medicinal Chemistry. 2008 Jul;51(14):4351-4355. |
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| 2008-07-21 |
吡咯啉啶化合物 |
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| 2008-07-01 |
Pyrrolidine compounds |
KR10-0844593/2008-07-01 |
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| 2008-07 |
Anti-HSV activity of digitoxin and its possible mechanisms |
Antiviral Research. 2008 Jul;79(1):62-70. |
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| 2008-06-01 |
A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors |
Analytical Biochemistry. 2008 Jun;377(1):89-94. |
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| 2008-05-01 |
抗腫瘤化合物 |
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| 2008-05 |
Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana |
Phytotherapy Research. 2008 May;22(5):605-613. |
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| 2008-04-15 |
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus |
Biochemical Pharmacology. 2008 Apr;75(8):1601-1609. |
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| 2008-03-13 |
Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors |
Journal of Medicinal Chemistry. 2008 Mar;51(5):1464-1468. |
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| 2008-03-10 |
Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent |
Tetrahedron. 2008 Mar;64(11):2586-2595. |
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| 2008-03-01 |
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627. |
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| 2008-02-11 |
一種抗病毒之醫藥組合物 |
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| 2008-02-07 |
First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol |
Organic Letters. 2008 Feb 7;10(3):449-452. |
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| 2008-02 |
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells |
Anti-Cancer Drugs. 2008 Feb;19(2):151-158. |
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| 2007-12 |
Strategies of development of antiviral agents directed against influenza virus replication |
Current Pharmaceutical Design. 2007 Dec;13(34):3531-3542. |
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| 2007-09-06 |
4-and 5-aroylindoles as novel classes of potent antitubulin agents |
Journal of Medicinal Chemistry. 2007 Sep;50(18):4548-4552. |
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| 2007-07-31 |
Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil |
British Journal of Cancer. 2007 Jul;97(3):334-344. |
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| 2007-07 |
Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes |
Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049. |
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| 2007-07 |
Anti-influenza drug discovery |
Drugs of the Future. 2007 Jul;32(Suppl. A):97. |
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| 2007-07 |
From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents |
Drugs of the Future. 2007 Jul;32(Suppl. A):34-35. |
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| 2007-03-01 |
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes |
Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279. |
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| 2007-02-08 |
Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells |
Cancer Letters. 2007 Feb;246(1-2):237-252. |
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| 2007-02-01 |
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study |
Journal of Chromatography B. 2007 Feb;846(1-2):162-168. |
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| 2006-12 |
Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats |
Journal of Food and Drug Analysis. 2006 Dec;14(4):329-333. |
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| 2006-11-16 |
7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents |
Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659. |
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| 2006-11 |
Combined modalities of resistance in an oxaliplaitin-resistant human gastric cancer cell line with enhanced sensitivity |
EJC Supplements. 2006 Nov;4(12):59. |
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| 2006-10-19 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists |
Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424. |
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| 2006-10 |
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents |
ChemMedChem. 2006 Oct;1(10):1106-1118. |
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| 2006-09 |
MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes |
Abstracts of Papers - American Chemical Society. 2006 Sep;232:MEDI 416. |
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| 2006-08-24 |
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease |
Journal of Medicinal Chemistry. 2006 Aug;49(17):5154-5161. |
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| 2006-07 |
Antiviral drug discovery against SARS-CoV |
Current Medicinal Chemistry. 2006 Jul;13(17):2003-2020. |
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ORCID:0000-0002-1332-005X6
