國家衛生研究院 NHRI:
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    近3年内发表的文件:14(6.03%)
    含全文笔数:172(74.14%)

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    下载大于0次:172(100.00%)
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    显示项目176-200 / 232. (共10页)
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    日期题名關聯
    2008-05-01 抗腫瘤化合物 I296195/2008-05-01
    2008-05 Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana Phytotherapy Research. 2008 May;22(5):605-613.
    2008-04-15 Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Biochemical Pharmacology. 2008 Apr;75(8):1601-1609.
    2008-03-13 Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors Journal of Medicinal Chemistry. 2008 Mar;51(5):1464-1468.
    2008-03-10 Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent Tetrahedron. 2008 Mar;64(11):2586-2595.
    2008-03-01 Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627.
    2008-02-11 一種抗病毒之醫藥組合物 I293248/2008-02-11
    2008-02-07 First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol Organic Letters. 2008 Feb 7;10(3):449-452.
    2008-02 A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells Anti-Cancer Drugs. 2008 Feb;19(2):151-158.
    2007-12 Strategies of development of antiviral agents directed against influenza virus replication Current Pharmaceutical Design. 2007 Dec;13(34):3531-3542.
    2007-09-06 4-and 5-aroylindoles as novel classes of potent antitubulin agents Journal of Medicinal Chemistry. 2007 Sep;50(18):4548-4552.
    2007-07-31 Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil British Journal of Cancer. 2007 Jul;97(3):334-344.
    2007-07 Biotransformation of 6-methoxy-3-(3 ',4 ',5 '-trimethoxy-benzoyl)-1-hindole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes Drug Metabolism and Disposition. 2007 Jul;35(7):1042-1049.
    2007-07 Anti-influenza drug discovery Drugs of the Future. 2007 Jul;32(Suppl. A):97.
    2007-07 From bench to drug candidate: Design and synthesis of 5,6-fused heteroaromatics as anticancer agents Drugs of the Future. 2007 Jul;32(Suppl. A):34-35.
    2007-03-01 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279.
    2007-02-08 Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells Cancer Letters. 2007 Feb;246(1-2):237-252.
    2007-02-01 Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study Journal of Chromatography B. 2007 Feb;846(1-2):162-168.
    2006-12 Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats Journal of Food and Drug Analysis. 2006 Dec;14(4):329-333.
    2006-11-16 7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659.
    2006-11 Combined modalities of resistance in an oxaliplaitin-resistant human gastric cancer cell line with enhanced sensitivity EJC Supplements. 2006 Nov;4(12):59.
    2006-10-19 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
    2006-10 Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents ChemMedChem. 2006 Oct;1(10):1106-1118.
    2006-09 MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes Abstracts of Papers - American Chemical Society. 2006 Sep;232:MEDI 416.
    2006-08-24 Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease Journal of Medicinal Chemistry. 2006 Aug;49(17):5154-5161.

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